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Erastin

    
98.1%

Erastin

源葉(MedMol)
S80804 一鍵復制產品信息
571203-78-6
C30H31ClN4O4
547.04
MFCD09837984
4(3H)-Quinazolinone, 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-
貨號 規格 價格 上海 北京 武漢 南京 購買數量
S80804-1mg
98.1% ¥230.00 >10 1 - -
S80804-2mg
98.1% ¥300.00 7 1 - -
S80804-5mg
98.1% ¥420.00 >10 - - -
S80804-10mg
98.1% ¥720.00 9 - - -
S80804-25mg
98.1% ¥900.00 10 - - -
S80804-50mg
98.1% ¥2400.00 8 - - -
S80804-100mg
98.1% ¥4600.00 8 - - -
產品介紹 參考文獻(15篇) 質檢證書(COA) 摩爾濃度計算器 相關產品

產品介紹

Erastin is a ferroptosis inducer. Erastin binds and inhibits voltage-dependent anion channels (VDAC2/VDAC3)

產品溶液形式不穩定,建議現配現用。開封后保存請加封口膜和密封袋在干燥處保存。

產品描述:

Erastin is a ferroptosis inducer. Erastin binds and inhibits voltage-dependent anion channels (VDAC2/VDAC3)

產品溶液形式不穩定,建議現配現用。開封后保存請加封口膜和密封袋在干燥處保存。

靶點: Ferroptosis;VDAC
體內研究: Intraperitoneal injection of erastin at well-tolerated doses dramatically inhibits HT-29 xenograft growth in severe combined immunodeficient mice
參考文獻: 1. Dixon SJ, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012 May 25;149(5):1060-72. 2. Xie Y, et al. Ferroptosis: process and function. Cell Death Differ. 2016 Mar;23(3):369-79. 3. Huo H, et al. Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells. PLoS One. 2016 May 12;11(5):e0154605.
溶解性: DMSO  :  12.5  mg/mL  (22.85  mM;  Need  ultrasonic)    H2O  :  <  0.1  mg/mL  (insoluble)
保存條件: -20℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 1.828 ml 9.14 ml 18.28 ml
5 mM 0.366 ml 1.828 ml 3.656 ml
10 mM 0.183 ml 0.914 ml 1.828 ml
50 mM 0.037 ml 0.183 ml 0.366 ml
注意: 部分產品我司僅能提供部分信息,我司不保證所提供信息的權威性,僅供客戶參考交流研究之用。

參考文獻(15篇)

10. [IF=4] Yinhao ZHANG et al."Rehmanniae Radix Praeparata aqueous extract improves hepatic ischemia/reperfusion injury by restoring intracellular iron homeostasis."Chinese Journal of Natural Medicines.2024 Sep;22:769 9. [IF=3.1] Jing Xin et al."Melatonin mitigates the lipopolysaccharide-induced myocardial injury in rats by blocking the p53/xCT pathway-mediated ferroptosis."NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY.2024 Aug;:1-11 8. [IF=5.8] Muran Jiang et al."Copper oxide nanoparticles induce cuproptosis and ferroptosis through mitochondrial concatenation."Environmental Science-Nano.2024 Jul;: 7. [IF=5.3] Xue Xiaoyong et al."Si-Wu-Tang alleviates metabolic dysfunction-associated fatty liver disease by inhibiting ACSL4-mediated arachidonic acid metabolism and ferroptosis in MCD diet-fed mice."Chinese Medicine.2024 Dec;19(1):1-22 6. [IF=3.7] Xianqi Zhang et al."Salidroside induces mitochondrial dysfunction and ferroptosis to inhibit melanoma progression through reactive oxygen species production."EXPERIMENTAL CELL RESEARCH".2024 May;438:114034 5. [IF=4.7] Sheng Hu et al."Ginsenoside Rd enhances blood-brain barrier integrity after cerebral ischemia/reperfusion by alleviating endothelial cells ferroptosis via activation of NRG1/ErbB4-mediated PI3K/Akt/mTOR signaling pathway."NEUROPHARMACOLOGY".2024 Jun;251:1 4. [IF=3.8] Zhang Yunwen et al."Knockdown of SLC39A14 inhibits glioma progression by promoting erastin-induced ferroptosis SLC39A14 knockdown inhibits glioma progression."BMC CANCER.2023 Dec;23(1):1-15 3. [IF=3] Zhang Meixia et al."NFE2L1 restrains ferroptosis by transcriptionally regulating HJURP and participates in the progress of oral squamous cell carcinoma."JOURNAL OF BIOENERGETICS AND BIOMEMBRANES.2023 Oct;:1-12 2. [IF=4.831] Ying Lan et al."Polysiloxane-based hyperbranched fluorescent probe for dynamic visualization of HClO in lysosomes and vivo."SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY.2023 Jun;294:122527 1. [IF=6.313] Yijia Yang et al."Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin."Antioxidants-Basel. 2022 Apr;11(4):710

質檢證書(COA)

如何獲取質檢證書(COA)?
請輸入貨號和一個與之匹配的批號。
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批號:JS298415 貨號:S20001-25g
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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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