| 貨號 | 規(guī)格 | 價格 | 上海 | 北京 | 武漢 | 南京 | 購買數(shù)量 |
|---|---|---|---|---|---|---|---|
| S81241-1mg | 99% | ￥320.00 | 1 | - | - | - |
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| S81241-2mg | 99% | ￥600.00 | 1 | - | - | - |
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| S81241-5mg | 99% | ￥980.00 | 5 | - | - | - |
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| S81241-10mg | 99% | ￥1800.00 | 4 | - | - | - |
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| S81241-25mg | 99% | ￥2400.00 | 2 | - | - | - |
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| S81241-50mg | 99% | ￥4000.00 | 1 | - | - | - |
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| S81241-100mg | 99% | ￥6000.00 | 2 | - | - | - |
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RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells
| 產(chǎn)品描述： | RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells | ||||||||||||||||||||
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| 靶點： | Glutathione peroxidase 4;Ferroptosis;?GPX;?GlutathionePeroxidase | ||||||||||||||||||||
| 體內(nèi)研究： | RSL3 (100 mg/kg, Intratumorally twice per week for 20 days) significantly inhibits the growth of tumor in combination with trigonelline in mice bearing HN3R cells. | ||||||||||||||||||||
| 參考文獻： | 1. Shin D, et al. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018 Dec;129:454-462. | ||||||||||||||||||||
| 溶解性： | DMSO : 100 mg/mL (226.82 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存條件： | -20℃ | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
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