貨號	規格	價格	上海	北京	武漢	南京
S84386-1mg	≥98%	￥200.00 S84386-1mg ￥200.00 現貨	1920 >10	-	-	-
S84386-5mg	99.4%	￥500.00 S84386-5mg ￥500.00 現貨	396 >10	-	-	-
S84386-10mg	99.4%	￥800.00 S84386-10mg ￥800.00 現貨	196 >10	-	-	-
S84386-25mg	99.4%	￥1200.00 S84386-25mg ￥1200.00 現貨	82 >10	-	-	-
S84386-50mg	99.4%	￥1800.00 S84386-50mg ￥1800.00 現貨	41 >10	-	-	-
S84386-100mg	99.4%	￥3200.00 S84386-100mg ￥3200.00 現貨	20 >10	-	-	-

產品介紹

MCC950 (CP-456773, CRID3) 是一種有效的 NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) 的選擇性抑制劑，在BMDMs和HMDMs中對應的IC50值分別為7.5 nM和8.1 nM

產品描述：

靶點：

NLRP3(BMDM-based assay):7.5 nM; NLRP3(HMDM-based assay):8.1 nM;NOD

體外研究：

MCC950 specifically inhibits NLPR3 inflammasome activation

體內研究：

Inhibition of NLRP3 with MCC950 ameliorates proteinuria, renal histological lesions and podocyte foot process effacement in lupus-prone mice

細胞實驗：

Cell lines: NZM2328 podocyte cell line Concentrations: 1 μM Incubation Time: 24 h Method: The NZM2328 podocyte cell line was stimulated with a control serum or a serum from diseased NZM2328 mice or serum from diseased NZM2328 mice depleted of IgG, with or without MCC950 or Mito TEMPO for 24 hours. After this incubation, cells were subjected to flow cytometry and Western blot analyses for NLRP3 inflammasome activation, mitochondrial membrane potential and production of reactive oxygen species (ROS) analysis.

動物實驗：

Animal Models: female NZM2328, a new NZM strain produced by extended backcrosses of NZB/WF1 to NZW mice Dosages: 10mg/kg Administration: i.p.

參考文獻：

1. Fu R, et al. Podocyte Activation of NLRP3 Inflammasomes Contributes to the Development of Proteinuria in Lupus Nephritis. Arthritis Rheumatol. 2017 Aug;69(8):1636-1646. 2. Joshi H, et al. L-plastin enhances NLRP3 inflammasome assembly and bleomycin-induced lung fibrosis. Cell Rep. 2022 Mar 15;38(11):110507. 3. Xie H, et al. Effects of mitochondrial reactive oxygen species-induced NLRP3 inflammasome activation on trichloroethylene-mediated kidney immune injury. Ecotoxicol Environ Saf. 2022 Oct 1;244:114067.

溶解性：

Soluble in DMSO、Ethanol

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.472 ml	12.362 ml	24.723 ml
5 mM	0.494 ml	2.472 ml	4.945 ml
10 mM	0.247 ml	1.236 ml	2.472 ml
50 mM	0.049 ml	0.247 ml	0.494 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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MCC950