貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S81447-2mg	98.1%	￥258.40 S81447-2mg ￥258.40 現(xiàn)貨	6 6	-	-	-
S81447-5mg	98.1%	￥408.00 S81447-5mg ￥408.00 現(xiàn)貨	1 1	-	-	-
S81447-10mg	98.1%	￥544.00 S81447-10mg ￥544.00 現(xiàn)貨	3 3	-	-	-
S81447-50mg	98.1%	￥2040.00 S81447-50mg ￥2040.00 現(xiàn)貨	5 0 5	-	-	-
S81447-100mg	98.1%	￥3060.00 S81447-100mg ￥3060.00 現(xiàn)貨	4 4	-	-	-
S81447-200mg	≥98%	￥4600.00 S81447-200mg ￥4600.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

MCC950 Sodium是一種有效的、選擇性NLRP3抑制劑，在骨髓來(lái)源的巨噬細(xì)胞中IC50為7.5 nM。對(duì)AIM2, NLRC4或NLRP1炎癥體沒(méi)有作用

產(chǎn)品描述：

MCC950 Sodium是一種有效的、選擇性NLRP3抑制劑，在骨髓來(lái)源的巨噬細(xì)胞中IC50為7.5 nM。對(duì)AIM2, NLRC4或NLRP1炎癥體沒(méi)有作用

靶點(diǎn)：

NLRP3(in BMDM (bone marrow derived macrophages)):7.5nM; NLRP3(in HMDM):8.1nM;NOD-likeReceptor(NLR);?NOD

體外研究：

MCC950在骨髓來(lái)源的巨噬細(xì)胞和人類單核細(xì)胞衍生的巨噬細(xì)胞中，抑制經(jīng)典和非經(jīng)典NLRP3激活，IC50分別為7.5和8.1 nM。MCC950特異性抑制NLRP3的激活，不抑制AIM2, NLRC4或NLRP1這些炎癥小體

體內(nèi)研究：

MCC950減少白介素-1β(IL-1β)的產(chǎn)生、減輕實(shí)驗(yàn)性自身免疫性腦脊髓炎的嚴(yán)重性。在自身炎癥性疾病Cryopyrin蛋白相關(guān)周期性綜合征的小鼠模型中，MCC950能夠挽救其新生時(shí)期的死亡。在間接體外實(shí)驗(yàn)中，在來(lái)源于韋二氏綜合征患者的樣品具有活性[

細(xì)胞實(shí)驗(yàn)：

Cell lines: H9c2 cardiomyocyte cells Concentrations: 7 nM Incubation Time: 24 h Method: Cardiomyocytes were treated with NLRP3 inhibitor MCC950 for 24?h.

動(dòng)物實(shí)驗(yàn)：

Animal Models: C57BL/6小鼠 Dosages: 50 mg/kg Administration: 腹腔注射

參考文獻(xiàn)：

1. Coll RC, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015, 21(3):248-55. 2. Meng L, et al. METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA. Cell Death Dis. 2022 Jan 10;13(1):38.

溶解性：

Soluble in H2O、Ethanol

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.345 ml	11.724 ml	23.449 ml
5 mM	0.469 ml	2.345 ml	4.69 ml
10 mM	0.234 ml	1.172 ml	2.345 ml
50 mM	0.047 ml	0.234 ml	0.469 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(5篇)

5. [IF=4.9] Xin Li et al."Paeonol Relieves Chronic Neuropathic Pain by Reducing Communication Between Schwann Cells and Macrophages in the Dorsal Root Ganglia After Injury."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2025 Jan;26(9):3964 4. [IF=4.7] Zou Hai et al."Cynaroside regulates the AMPK/SIRT3/Nrf2 pathway to inhibit doxorubicin-induced cardiomyocyte pyroptosis."Journal of Zhejiang University-SCIENCE B.2024 Sep;:1-17 3. [IF=5.5] Waimei Si et al."Stigmasterol alleviates neuropathic pain by reducing Schwann cell-macrophage cascade in DRG by modulating IL-34/CSF1R."CNS Neuroscience & Therapeutics".2024 Apr;30(4):e14657 2. [IF=13.6] Meitong Liu et al."Sodium sulfite triggered hepatic apoptosis, necroptosis, and pyroptosis by inducing mitochondrial damage in mice and AML-12 cells."JOURNAL OF HAZARDOUS MATERIALS".2024 Apr;467:133719 1. [IF=7.5] Jiashe Chen et al."Chlorogenic acid attenuates deoxynivalenol-induced apoptosis and pyroptosis in human keratinocytes via activating Nrf2/HO-1 and inhibiting MAPK/NF-κB/NLRP3 pathways."BIOMEDICINE & PHARMACOTHERAPY.2024 Jan;170:116003

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MCC950 (sodium)