貨號	規格	價格	上海	北京	武漢	南京
S81846-5mg	98.9%	￥370.00 S81846-5mg ￥370.00 現貨	6 6	-	-	-
S81846-10mg	98.9%	￥630.00 S81846-10mg ￥630.00 現貨	6 6	-	-	-
S81846-25mg	98.9%	￥1260.00 S81846-25mg ￥1260.00 現貨	6 6	-	-	-
S81846-50mg	≥98%	￥2082.00 S81846-50mg ￥2082.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

Hydroxyfasudil is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively.

產品描述：

Hydroxyfasudil is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively.

靶點：

ROCK;ROCK;?PKA

體內研究：

Hydroxyfasudil (10 mg/kg, i.p.) significantly increases both the average and maximal voided volumes in SD rats. Hydroxyfasudil also significantly decreases the maximal detrusor pressure. Hydroxyfasudil (3 mg/kg, i.p) inhibits hypercontractility induced by norepinephrine in spontaneously hypertensive rats (SHRs). Furthermore, Hydroxyfasudil (3, 10 mg/kg, i.p) significantly ameliorates decreased penile cGMP contents in rats

參考文獻：

1. Rikitake Y, et al. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke. 2005 Oct;36(10):2251-7. Epub 2005 Sep 1. 2. Masago T, et al. Effect of the rho-kinase inhibitor hydroxyfasudil on bladder overactivity: an experimental rat model. Int J Urol. 2009 Oct;16(10):842-7. 3. Saito M, et al. Hydroxyfasudil ameliorates penile dysfunction in the male spontaneously hypertensive rat. Pharmacol Res. 2012 Oct;66(4):325-31.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.253 ml	16.267 ml	32.534 ml
5 mM	0.651 ml	3.253 ml	6.507 ml
10 mM	0.325 ml	1.627 ml	3.253 ml
50 mM	0.065 ml	0.325 ml	0.651 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

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Hydroxyfasudil