貨號	規格	價格	上海	北京	武漢	南京
S81365-5mg	99.1%	￥510.00 S81365-5mg ￥510.00 現貨	5 5	-	-	-
S81365-10mg	99.1%	￥765.00 S81365-10mg ￥765.00 現貨	6 6	-	-	-
S81365-50mg	99.1%	￥3145.00 S81365-50mg ￥3145.00 現貨	4 4	-	-	-
S81365-100mg	99.1%	￥4675.00 S81365-100mg ￥4675.00 現貨	2 2	-	-	-

產品介紹

Hydroxyfasudil hydrochloride is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively.

產品描述：

Hydroxyfasudil hydrochloride is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively.

靶點：

ROCK2:0.72 μM (IC50);ROCK1:0.73 μM (IC50);PKA:37 μM (IC50)

體內研究：

Hydroxyfasudil (10 mg/kg, i.p.) significantly increases both the average and maximal voided volumes in SD rats. Hydroxyfasudil also significantly decreases the maximal detrusor pressure. Hydroxyfasudil (3 mg/kg, i.p) inhibits hypercontractility induced by norepinephrine in spontaneously hypertensive rats (SHRs). Furthermore, Hydroxyfasudil (3, 10 mg/kg, i.p) significantly ameliorates decreased penile cGMP contents in rats

參考文獻：

1. Rikitake Y, et al. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke. 2005 Oct;36(10):2251-7. Epub 2005 Sep 1. 2. Masago T, et al. Effect of the rho-kinase inhibitor hydroxyfasudil on bladder overactivity: an experimental rat model. Int J Urol. 2009 Oct;16(10):842-7. 3. Saito M, et al. Hydroxyfasudil ameliorates penile dysfunction in the male spontaneously hypertensive rat. Pharmacol Res. 2012 Oct;66(4):325-31.

溶解性：

Soluble in DMSO、H2O

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.908 ml	14.542 ml	29.084 ml
5 mM	0.582 ml	2.908 ml	5.817 ml
10 mM	0.291 ml	1.454 ml	2.908 ml
50 mM	0.058 ml	0.291 ml	0.582 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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HYDROXYFASUDIL MONOHYDROCHLORIDE