產品介紹

有效的選擇性EGF受體酪氨酸激酶;Potent, selective EGF receptor tyrosine kinase;AG-494 (Tyrphostin AG 494) is a potent and selective?EGFR?tyrosine kinase inhibitor (IC50=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis;AG-494 (Tyrphostin AG 494) is a potent and selective?EGFR?tyrosine kinase inhibitor (IC50=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis