產(chǎn)品介紹

非特異性自由基清除劑。抗氧化劑。;Non-specific free radical scavenger. Anti-oxidant.;幾乎無味。本品在水中幾乎不溶，水中溶解度：1 g/L (20°C) 。溶于10% NaOH溶液，溶于脂肪族溶劑。在乙醇、氯仿、乙醚中易溶。?抗氧化劑和作為如丙酮酸脫氫酶(pyruvate dehydrogenase） 和甘氨酸脫羧酶（glycine decarboxylase）的輔酶，外源性硫辛酸被細(xì)胞內(nèi)兩種或多種酶還原。這種還原形式影響了細(xì)胞清除自由基的進(jìn)程。增加谷胱甘肽(glutathione)合成, 調(diào)控轉(zhuǎn)錄因子活性。降低了巨噬細(xì)胞髓磷脂的吞噬作用。α-LA可以恢復(fù)高脂肪喂養(yǎng)的糖尿病大鼠的內(nèi)皮活動，并減輕氧化應(yīng)激。它還用于分析星形膠質(zhì)細(xì)胞中的ROS 產(chǎn)生。;α-Lipoic acid (LA), a nutritional component found in vegetables and meat, has both antioxidant and oxidant properties. LA exerts therapeutic potential to many diseases like liver cirrhosis, heavy metal poisoning, and diabetic polyneuropathy. LA exerts apoptotic potential in cancer cells either by oxidative stress related pathway or by activation of caspases.DL-Thioctic acid acid has been used in in vitro lipoylation studies and in the pyruvate dehydrogenase complex (PDC)-pyruvate dehydrogenase kinase (PDHK) functional assay.It has also been used to investigate its antioxidative effect on developing cerebellum of rats exposed to arsenic during postnatal period;DL-Thioctic acid can reinstate endothelial activities and alleviate oxidative stress in high-fat fed diabetic rats. It has also been used to analyze ROS production in astrocytes