貨號	規(guī)格	價格	上海	北京	武漢	南京
S89975-2mg	98.5%	￥400.00 S89975-2mg ￥400.00 現(xiàn)貨	10 10	-	-	-
S89975-5mg	98.5%	￥800.00 S89975-5mg ￥800.00 現(xiàn)貨	2 2	-	-	-
S89975-25mg	98.5%	￥2400.00 S89975-25mg ￥2400.00 現(xiàn)貨	2 2	-	-	-
S89975-100mg	≥98%	￥5600.00 S89975-100mg ￥5600.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

Elimusertib (BAY-1895344) is a very potent and highly selective ATR (ataxia telangiectasia and Rad3-related) inhibitor with IC50 of 7 nM. Elimusertib potently inhibits proliferation of a broad spectrum of human tumor cell lines with median IC50 of 78 nM.

產(chǎn)品描述：

靶點：

ATR(Cell-free assay):7 nM;ATM/ATR

體外研究：

BAY-1895344 inhibits tumor cell growth and viability and exhibits potent antiproliferative activity in a broad spectrum of human tumor cell lines

體內(nèi)研究：

BAY 1895344 exhibits strong monotherapy efficacy in cancer xenograft models that carry DNA damage repair deficiencies.

細胞實驗：

Cell lines: HT-29 cells, M059J cells, 38 cancer cell lines Concentrations: 3–300 nM Incubation Time: 72 to 96 hours Method: The antiproliferative activity of BAY 1895344 is evaluated against a panel of 38 cancer cell lines. Cell proliferation is measured after 72 to 96 hours of exposure to BAY1895344. Cell viability is determined using crystal violet staining or the CellTiter-Glo Cell Viability Assay.

動物實驗：

Animal Models: female SCID beige mice, female C.B-17 SCID mice, male NMRI nude mice, female NMRI nude mice Dosages: 50 mg/kg Administration: Oral gavage

參考文獻：

1. Ulrich T. Luecking, et al. Cancer Res 2017;77(13 Suppl):Abstract nr 983. 2. Antje M Wengner, et al. Mol Cancer Ther. 2020 Jan;19(1):26-38.

溶解性：

Soluble in DMSO、Ethanol

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.428 ml	12.139 ml	24.278 ml
5 mM	0.486 ml	2.428 ml	4.856 ml
10 mM	0.243 ml	1.214 ml	2.428 ml
50 mM	0.049 ml	0.243 ml	0.486 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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Elimusertib hydrochloride

BAY-1895344 hydrochloride