貨號	規格	價格	上海	北京	武漢	南京	購買數量
S89645-25mg	≥98%(HPLC)	￥480.00 S89645-25mg ￥480.00 現貨	2 2	-	-	-
S89645-100mg	≥98%(HPLC)	￥1048.00 S89645-100mg ￥1048.00 現貨	1 1	-	-	-

產品介紹

Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells

產品描述：

靶點：

Topoisomerase I;Topoisomerase

參考文獻：

1. Burris HA 3rd, et al. Phase II trial of oral rubitecan in previously treated pancreatic cancer patients. Oncologist. 2005 Mar;10(3):183-90. 2. Rubitecan: 9-NC, 9-Nitro-20(S)-camptothecin, 9-nitro-camptothecin, 9-nitrocamptothecin, RFS 2000, RFS2000. Drugs R D. 2004;5(5):305-11. 3. Rubitecan 4. Xia M, et al. Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther. 2013 Jul;14(7):638-47.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.542 ml	12.711 ml	25.423 ml
5 mM	0.508 ml	2.542 ml	5.085 ml
10 mM	0.254 ml	1.271 ml	2.542 ml
50 mM	0.051 ml	0.254 ml	0.508 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(2篇)

2. [IF=9.965] Jianqin Yan et al."Autophagy-induced intracellular signaling fractional nano-drug system for synergistic anti-tumor therapy."JOURNAL OF COLLOID AND INTERFACE SCIENCE.2023 May;: 1. [IF=7.79] Yalin Sun et al."Novel polymeric micelles as enzyme-sensitive nuclear-targeted dual-functional drug delivery vehicles for enhanced 9-nitro-20(S)-camptothecin delivery and antitumor efficacy."Nanoscale. 2020 Mar;12(9):5380-5396

質檢證書(COA)

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質量

濃度

體積

分子摩爾量

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魯比特康

Rubitecan