貨號	規格	價格	上海	北京	武漢	南京
S89396-5mg	99.6%	￥850.00 S89396-5mg ￥850.00 現貨	6 6	-	-	-
S89396-10mg	99.6%	￥1360.00 S89396-10mg ￥1360.00 現貨	6 6	-	-	-
S89396-25mg	99.6%	￥2550.00 S89396-25mg ￥2550.00 現貨	6 6	-	-	-
S89396-100mg	≥98%	￥6200.00 S89396-100mg ￥6200.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM. ZINC05007751 shows antiproliferative activity against a panel of human cancer cell lines, and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity was observed against NEK2, NEK7, and NEK9

產品描述：

靶點：

MAPK

體外研究：

ZINC05007751 (6 μM-190 μM; 24 hours) inhibits the growth of MDA-MB-231, PEO1, NCI-H1299 and HCT-15 with IC50 below 100?μM. ZINC05007751 induces perturbation of PEO1 cell cycle. ZINC05007751 (ovarian cancer cells PEO1) shows synergism with Cisplatin, resulting in a significant reduction of Cisplatin IC50 from 7.9 to 0.1??μM, with combination ZINC05007751 (44?μM)?+?Cisplatin (10?μM) exhibiting the greatest synergistic effect. Cell Cytotoxicity Assay Cell Line: MDA-MB-231, PEO1, NCI-H1299 and HCT-15 cells Concentration: 6 μM-190 μM Incubation Time: 24?hours Result: Inhibited the growth of MDA-MB-231, PEO1, NCI-H1299 and HCT-15.

參考文獻：

1. De Donato M, et al. Identification and antitumor activity of a novel inhibitor of the NIMA-related kinase NEK6. Sci Rep. 2018;8(1):16047. Published 2018 Oct 30.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.286 ml	16.431 ml	32.862 ml
5 mM	0.657 ml	3.286 ml	6.572 ml
10 mM	0.329 ml	1.643 ml	3.286 ml
50 mM	0.066 ml	0.329 ml	0.657 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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ZINC05007751

(Z)-4-Methyl-2,6-dioxo-5-((5-phenylfuran-2-yl)methylene)-1,2,5,6-tetrahydropyridine-3-carbonitrile