貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S89316-5mg	99.7%	￥660.00 S89316-5mg ￥660.00 現(xiàn)貨	206 >10	-	-	-
S89316-10mg	99.7%	￥910.00 S89316-10mg ￥910.00 現(xiàn)貨	106 >10	-	-	-
S89316-50mg	99.7%	￥2900.00 S89316-50mg ￥2900.00 現(xiàn)貨	26 >10	-	-	-
S89316-100mg	99.7%	￥4300.00 S89316-100mg ￥4300.00 現(xiàn)貨	16 >10	-	-	-

產(chǎn)品介紹

Encequidar mesylate (HM30181 mesylate; HM30181A mesylate) is a competitive and potent P-glycoprotein inhibitor

產(chǎn)品描述：

Encequidar mesylate (HM30181 mesylate; HM30181A mesylate) is a competitive and potent P-glycoprotein inhibitor

靶點(diǎn)：

P-glycoprotein;P-gp

體外研究：

Treatment of 0.1 or 1 nM Encequidar (HM30181) lead to 20 and 42% inhibition of survival at the 100 nM and 1000 nM NSC 125973 treatment, respectively.

體內(nèi)研究：

The plasma concentrations of Encequidar (HM30181) are higher for the simultaneous administration with the microcapsule than with the powder; providing significant differences from 1 to 2 h. The microcapsule has about a 1.7-fold faster Tmax and a 1.6-fold higher AUC value compared with the powder (2.5±0.6 vs. 4.3±0.9 h; 107.7±20.1 vs. 64.3±18.0 h ng/mL). The faster and overall improved absorption of Encequidar (HM30181) in microcapsule form might be due to the remarkable enhancement of the aqueous solubility and dissolution resulting from its crystalline conversion to the amorphous form and particle size reduction.

參考文獻(xiàn)：

1. Kim JC, et al. Effect of HM30181 mesylate salt-loaded microcapsules on the oral absorption of NSC 125973 as a novel P-glycoprotein inhibitor. Int J Pharm. 2016 Jun 15;506(1-2):93-101. 2. Joo KM, et al. Response of brain specific microenvironment to P-glycoprotein inhibitor: an important factor determining therapeutic effect of P-glycoprotein inhibitor on brain metastatic tumors. Int J Oncol. 2008 Oct;33(4):705-12.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.274 ml	6.371 ml	12.742 ml
5 mM	0.255 ml	1.274 ml	2.548 ml
10 mM	0.127 ml	0.637 ml	1.274 ml
50 mM	0.025 ml	0.127 ml	0.255 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(COA)

輸入產(chǎn)品批號(hào)：

如何獲取質(zhì)檢證書(COA)?

請(qǐng)輸入貨號(hào)和一個(gè)與之匹配的批號(hào)。
例如:
批號(hào)：JS298415 貨號(hào)：S20001-25g
在貨品標(biāo)簽上如何找到貨號(hào)和批號(hào)?

摩爾濃度計(jì)算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質(zhì)量

濃度

體積

分子摩爾量

計(jì)算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费

Encequidar mesylate