貨號	規格	價格	上海	北京	武漢	南京
S88198-5mg	99.4%	￥297.50 S88198-5mg ￥297.50 現貨	6 6	-	-	-
S88198-10mg	99.4%	￥552.50 S88198-10mg ￥552.50 現貨	7 7	-	-	-
S88198-25mg	99.4%	￥935.00 S88198-25mg ￥935.00 現貨	6 6	-	-	-
S88198-50mg	99.4%	￥1640.00 S88198-50mg ￥1640.00 現貨	5 5	-	-	-
S88198-100mg	≥98%	￥2650.00 S88198-100mg ￥2650.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

Varenicline (CP 526555) dihydrochloride is a potent partial agonist for α4β2 nicotinic acetylcholine receptor (nAChR) with an EC50 value of 2.3 μM. Varenicline dihydrochloride is a full agonist for α3β4 and α7 nAChRs with EC50 values of 55 μM and 18 μM, respectively. Varenicline dihydrochloride is a nicotinic ligand based on the structure of cytosine, and has the potential for smoking cessation treatment

產品描述：

靶點：

EC50: 2.3 μM (α4β2 nAChR); 18 μM (α7 nAChR); 55 μM (α3β4 nAChR);AChR

體內研究：

Varenicline dihydrochloride (Subcutaneous injection, 0.01-1 mg/kg, 3 days) given 10 min prior to nicotine (0.5 mg/kg, s.c.) inhibits nicotine conditioned place preference (CPP). Varenicline dihydrochloride (Subcutaneous injection, 2.5 mg/kg, 3 days) results in a place aversion which is dependent on α5 nAChRs but not β2 nAChRs. Varenicline dihydrochloride (Subcutaneous injection, 0.1 and 0.5 mg/kg, 3 days) reverses nicotine withdrawal signs such as hyperalgesia and somatic signs and withdrawal-induced aversion in a dose-related manner. Animal Model: ICR male mice Dosage: 0.01-1 mg/kg for 3 days Administration: Subcutaneous injection Result: Inhibited nicotine conditioned place preference (CPP) in a dose dependent manner.

參考文獻：

1. Elif Baris, et al. Varenicline Prevents LPS-Induced Inflammatory Response via Nicotinic Acetylcholine Receptors in RAW 264.7 Macrophages. Front Mol Biosci. 2021 Oct 12;8:721533. 2. Mihalak KB, et al. Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors.Mol Pharmacol. 2006 Sep;70(3):801-5. Epub 2006 Jun 9. 3. Jin H, et al. Therapeutic concentrations of varenicline in the presence of nicotine increase action potential firing in human adrenal chromaffin cells. J Neurochem. 2017 Jan;140(1):37-52. 4. Mitsuhisa Koga, et al. Varenicline promotes endothelial cell migration by lowering vascular endothelial-cadherin levels via the activated α7 nicotinic acetylcholine receptor-mitogen activated protein kinase axis. Toxicology. 2017 Sep 1;390:1-9. 5. Bagdas D, et al. New insights on the effects of varenicline on nicotine reward, withdrawal and hyperalgesia in mice.Neuropharmacology. 2018 Aug;138:72-79.

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.47 ml	17.348 ml	34.697 ml
5 mM	0.694 ml	3.47 ml	6.939 ml
10 mM	0.347 ml	1.735 ml	3.47 ml
50 mM	0.069 ml	0.347 ml	0.694 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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Varenicline-d4 Dihydrochloride (Major)