貨號	規格	價格	上海	北京	武漢	南京
S88013-5mg	99.8%	￥204.00 S88013-5mg ￥204.00 現貨	7 7	-	-	-
S88013-10mg	99.8%	￥340.00 S88013-10mg ￥340.00 現貨	6 6	-	-	-
S88013-50mg	99.8%	￥1156.00 S88013-50mg ￥1156.00 現貨	6 6	-	-	-
S88013-100mg	99.8%	￥2050.00 S88013-100mg ￥2050.00 現貨	5 5	-	-	-

產品介紹

Dyngo-4a是一種有效的dynamin抑制劑，作用于DynI (brain)，DynI (rec)，和DynII (rec)，IC50分別為0.38 μM，1.1?μM，和 2.3 μM

產品描述：

Dyngo-4a是一種有效的dynamin抑制劑，作用于DynI (brain)，DynI (rec)，和DynII (rec)，IC50分別為0.38 μM，1.1?μM，和 2.3 μM

靶點：

DynI (brain):0.38 μM;DynI (rec):1.1 μM;DynII (rec):2.3 μM;Dynamin

細胞實驗：

Cell lines: αT3–1 or LβT2 cells Concentrations: 30 μM Incubation Time: 30 minutes Method: αT3-1 or LβT2 cells (2 × 106) were grown overnight in a 6-well culture dish and then serum starved for 2–4 hours. Cells were pretreated with either vehicle (0), dynasore (80μM), or dyngo (30μM) for 30 minutes. For dose-response studies, indicated doses of dynasore were used for a 30-minute pretreatment. After pretreatment, cells were treated with 0 or GnRHa (10 nM) for 10 minutes. Cells were then washed twice in PBS, lysed in radio-immunoprecipitation assay (RIPA) buffer and subjected to SDS-PAGE (acrylamide:bis-acrylamide ratio of 29:1) and electroblotted to polyvinylidene difluoride membranes.

動物實驗：

Animal Models: Female CD-1 mice Dosages: 30 mg/kg Administration: i.p.

參考文獻：

1. McCluskey A, et al. Traffic. 2013, 14(12), 1272-1289. 2. Harper CB, et al. J Biol Chem. 2011, 286(41), 35966-35976. 3. Gagliardi M, et al. J Cell Sci. 2014, 127(22), 4918-4926. 4. Harper CB, et al. J Biol Chem. 2011, 286(41):35966-76. 5. Edwards BS, et al. Endocrinology. 2016, 157(2):831-43.

溶解性：

Soluble in DMSO、Ethanol

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.956 ml	14.779 ml	29.559 ml
5 mM	0.591 ml	2.956 ml	5.912 ml
10 mM	0.296 ml	1.478 ml	2.956 ml
50 mM	0.059 ml	0.296 ml	0.591 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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