貨號	規格	價格	上海	北京	武漢	南京
S87862-5mg	97.1%	￥612.00 S87862-5mg ￥612.00 現貨	3 3	-	-	-
S87862-10mg	97.1%	￥1020.00 S87862-10mg ￥1020.00 現貨	7 7	-	-	-
S87862-25mg	97.1%	￥2040.00 S87862-25mg ￥2040.00 現貨	6 6	-	-	-
S87862-100mg	≥97%	￥6120.00 S87862-100mg ￥6120.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes

產品描述：

T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes

靶點：

IC50: 6.75 pM (MMP-13);MMP

體外研究：

T-26c significantly inhibits the breakdown of collagen (87.4% inhibition at 0.1 μM) in IL-1β and oncostatin M stimulated cartilage.

體內研究：

T-26c is well absorbed in all species at the oral dose of 10–20 mg/kg. Oral administration of the disodium salt formulations of T-26c to guinea pigs results in significant increases in AUC (8357 ng h/mL) and Cmax (1445 ng/ mL) compared with those of the free acid T-26c (AUC = 6478 ng h/ mL and Cmax= 911 ng/mL).

參考文獻：

1. Nara H, et al. Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site. Bioorg Med Chem. 2014 Oct 1;22(19):5487-505.

溶解性：

Soluble in DMSO

保存條件：

-20°C

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.085 ml	10.427 ml	20.855 ml
5 mM	0.417 ml	2.085 ml	4.171 ml
10 mM	0.209 ml	1.043 ml	2.085 ml
50 mM	0.042 ml	0.209 ml	0.417 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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