貨號	規格	價格	上海	北京	武漢	南京
S87861-1mg	99.3%	￥280.00 S87861-1mg ￥280.00 現貨	9 9	-	-	-
S87861-5mg	99.3%	￥761.00 S87861-5mg ￥761.00 現貨	11 >10	-	-	-
S87861-10mg	99.3%	￥1196.00 S87861-10mg ￥1196.00 現貨	8 8	-	-	-
S87861-25mg	99.3%	￥1690.00 S87861-25mg ￥1690.00 現貨	11 >10	-	-	-
S87861-50mg	99.3%	￥2550.00 S87861-50mg ￥2550.00 現貨	11 >10	-	-	-

產品介紹

Gap 26 is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif

產品描述：

Gap 26 is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif

靶點：

Gap Junction Protein;GapJunctionProtein

體外研究：

Gap 26 (0.25 mg/mL, 30 min) reduces the wave size in the three cell lines (RBE4, SV-ARBEC and ECV304). Gap 26 (0.25 mg/mL, 30 min) completely abolishes the InsP3-triggered ATP response and reduced the ATP release to below the control level, indicating that the basal ATP release is also affected。
Gap 26 does indeed significantly inhibit our InsP3-triggered intercellular calcium waves, but it did not have any effect on dye coupling through junctional channels as evidenced by the FRAP experiments, despite the fact that connexin 43 was present in the cell lines used。
Gap 26 (100-300 μM) dose-dependently reduces the rhythmic responses of rabbit superior mesenteric arteries, with IC50 of 28.4 ± 3.4 μM。

參考文獻：

1. Katleen Braet, et al. Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium. 2003 Jan;33(1):37-48. 2. Chaytor AT, et al. Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries. J Physiol. 1997 Aug 15;503 ( Pt 1):99-110.

溶解性：

Soluble in H2O

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	0.645 ml	3.224 ml	6.448 ml
5 mM	0.129 ml	0.645 ml	1.29 ml
10 mM	0.064 ml	0.322 ml	0.645 ml
50 mM	0.013 ml	0.064 ml	0.129 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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GAP26

GAP 26