貨號	規格	價格	上海	北京	武漢	南京
S87740-5mg	98.6%	￥520.00 S87740-5mg ￥520.00 現貨	5 5	-	-	-
S87740-10mg	98.6%	￥880.00 S87740-10mg ￥880.00 現貨	4 4	-	-	-
S87740-25mg	98.6%	￥1760.00 S87740-25mg ￥1760.00 現貨	5 5	-	-	-
S87740-100mg	98.6%	￥4250.00 S87740-100mg ￥4250.00 現貨	3 3	-	-	-

產品介紹

SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway. BMPs are members of the transforming growth factor beta (TGFβ) family of secreted signaling molecules

產品描述：

靶點：

BMP;TGF-beta/Smad

體外研究：

Embryos treated with SJ000291942 display the most severe ventralization and SJ000291942 is also the most potent. SJ000291942 also causes more mortality, and at lower doses than controls and the other two compounds. This demonstrates our compounds cause ventralization of embryos consistent with increased BMP signaling activity. SJ000291942 causes an increase in bmp2b and szl expression. Zebrafish assays suggest that SJ000291942 activates the canonical BMP signaling pathway. To extend these observations, immunoblotting of protein lysates from C33A-2D2 cells stimulated with SJ000291942 at different times is performed. SJ000291942 activates phosphorylation of SMAD1/5/8 in serum-free medium. Like in zebrafish embryos, SJ000291942 is most active. SJ000291942 induces p-SMAD1/5/8 maximally at 1hr of treatment. Immunoblotting analysis of lysates from C33A-2D2 treated with SJ000291942 reveals clear induction of the phosphorylated Extracellular Signal-regulated protein Kinase, ERK1/2 (P-ERK1/2) by SJ000291942. The highest dose (100 and 300ng) BMP4 treatments generate a gene expression signature most similar to osteoblast expression. Low dose (10ng) BMP4 treatment aligns closely with 25μM compound 3 treatment and with 25μM SJ000291942。

參考文獻：

1. Genthe JR, et al. Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway. ACS Chem Biol. 2017 Sep 15;12(9):2436-2447.

溶解性：

Soluble in DMSO

保存條件：

-20°C

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.142 ml	15.708 ml	31.417 ml
5 mM	0.628 ml	3.142 ml	6.283 ml
10 mM	0.314 ml	1.571 ml	3.142 ml
50 mM	0.063 ml	0.314 ml	0.628 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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