貨號	規格	價格	上海	北京	武漢	南京
S87719-5mg	98%	￥640.00 S87719-5mg ￥640.00 現貨	6 6	-	-	-
S87719-10mg	98%	￥1040.00 S87719-10mg ￥1040.00 現貨	7 7	-	-	-
S87719-25mg	98%	￥2080.00 S87719-25mg ￥2080.00 現貨	6 6	-	-	-
S87719-100mg	98%	￥5600.00 S87719-100mg ￥5600.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

APD597 is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119. IC50 value: 46 nM (EC50) Target: hGPR119 The design and synthesis of a second generation GPR119-agonist clinical candidate for the treatment of diabetes is described. APD597 was selected for preclinical development based on a good balance between agonist potency, intrinsic activity and in particular on its good solubility and reduced drug-drug interaction potential.

產品描述：

靶點：

GPR119;GPR

參考文獻：

1. Buzard DJ, et al. Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4332-4335. 2. Huan Y, et al. The dual DPP4 inhibitor and GPR119 agonist HBK001 regulates glycemic control and beta cell function ex and in vivo. Sci Rep. 2017 Jun 28;7(1):4351. 3. Semple G, et al. Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improvedprofile. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1750-1755.

溶解性：

Soluble in DMSO

保存條件：

-20°C

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.085 ml	10.426 ml	20.853 ml
5 mM	0.417 ml	2.085 ml	4.171 ml
10 mM	0.209 ml	1.043 ml	2.085 ml
50 mM	0.042 ml	0.209 ml	0.417 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

質檢證書(COA)

輸入產品批號：

如何獲取質檢證書(COA)?

請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標簽上如何找到貨號和批號?

摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質量

濃度

體積

分子摩爾量

計算重置

玖玖资源网站,爆乳久久久,日韩精品乱码久久久蜜桃,精品呦国产一区二区三区,国产伦高清一区二区三区,sese一区二区,午夜精品福利一区二区三区,三级黄色网站久久免费

APD597