| 產品描述： | GLX351322 is an inhibitor of NADPH oxidase 4 (Nox4), and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM. |
| 靶點： |
IC50: 5 μ M (NOX4, cell assay), 40 μM (NOX2, cell assay);NADPH-oxidase;?NADPH |
| 體外研究： |
GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM. GLX351322 shows weak activity against NOX2 in hPBMC cells (IC50, 40 μM). |
| 體內研究： |
GLX351322 (3.8 mg/kg/day, p.o.) ameliorates HFD-induced hyperglycemia in mice |
| 參考文獻： |
1. Anvari E, et al. The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice. Free Radic Res. 2015;49(11):1308-18. |
| 溶解性： |
Soluble in DMSO |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.317 ml |
11.587 ml |
23.174 ml |
| 5 mM |
0.463 ml |
2.317 ml |
4.635 ml |
| 10 mM |
0.232 ml |
1.159 ml |
2.317 ml |
| 50 mM |
0.046 ml |
0.232 ml |
0.463 ml |
|
| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經營許可證（不帶存儲）
營業執照(三證合一)
北京