貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S87516-10mg	99.8%	￥95.00 S87516-10mg ￥95.00 現(xiàn)貨	7 7	-	-	-
S87516-25mg	99.8%	￥190.00 S87516-25mg ￥190.00 現(xiàn)貨	6 6	-	-	-
S87516-50mg	99.8%	￥335.00 S87516-50mg ￥335.00 現(xiàn)貨	6 6	-	-	-
S87516-100mg	99.8%	￥620.00 S87516-100mg ￥620.00 現(xiàn)貨	5 5	-	-	-

產(chǎn)品介紹

DY131 (GSK 9089) is a potent and selective ERRγ and ERRβ agonist. DY131displays inactive against ERRα, ERα and ERβ[1][2]. DY131 also inhibits Smo signaling

產(chǎn)品描述：

DY131 (GSK 9089) is a potent and selective ERRγ and ERRβ agonist. DY131displays inactive against ERRα, ERα and ERβ[1][2]. DY131 also inhibits Smo signaling

靶點(diǎn)：

ERRγ;ERRβ;EstrogenReceptor/ERR;?Estrogen/progestogenReceptor;?Smo

體內(nèi)研究：

DY131 (5 μg/kg; subcutaneous injection; every second day; for 12 days) treatment increases P450 side-chain cleavage (P450scc), StAR and HMGCoA reductase (HMGCR) while decreases hormone sensitive lipase (HSL) expressions. Animal Model: Mature male mice (C57BL/6) (8-10 week-old; ~24.3 g)[5] Dosage: 5 μg/kg Administration: Subcutaneous injection; every second day; for 12 days Result: Increased P450scc, StAR and HMGCR while decreased HSL expressions.

參考文獻(xiàn)：

1. Yu S, et al. ERRgamma suppresses cell proliferation and tumor growth of androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer. Cancer Res. 2007;67(10):4904-14. 2. Donna D. Yu, Barry Marc Forman. Identification of an agonist ligand for estrogen-related receptors ERRβ/γ. Bioorganic & Medicinal Chemistry Letters. 2005,15(5): 1311-1313. 3. Wang Y, et al. Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation . ACS Chem Biol. 2012,15;7(6):1040-8. 4. Yamamoto T, et al. Estrogen-related receptor-γ regulates estrogen receptor-α responsiveness in uterine endometrial cancer. Int J Gynecol Cancer. 2012;22(9):1509-16. 5. A Pacwa, et al. Interplay between estrogen-related receptors and steroidogenesis-controlling molecules in adrenals. In vivo and in vitro study. Acta Histochem. 2018 Jul;120(5):456-467.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.212 ml	16.058 ml	32.115 ml
5 mM	0.642 ml	3.212 ml	6.423 ml
10 mM	0.321 ml	1.606 ml	3.212 ml
50 mM	0.064 ml	0.321 ml	0.642 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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