貨號	規格	價格	上海	北京	武漢	南京
S87488-5mg	98.0%	￥1630.00 S87488-5mg ￥1630.00 現貨	14 >10	-	-	-
S87488-10mg	98.0%	￥2390.00 S87488-10mg ￥2390.00 現貨	7 7	-	-	-
S87488-25mg	98.0%	￥3760.00 S87488-25mg ￥3760.00 現貨	5 5	-	-	-

產品介紹

BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties

產品描述：

BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties

靶點：

BNC105 exhibited excellent potency against a panel of different cancer cell lines with IC50 <1 nM for DU145, Calu-6, MDA-MB-231 etc. The selectivity observed for BNC105 against activated over quiescent HUVECs was also observed in human aortic arterial endothelial cells (HAAECs). BNC105 also exhibited good potency toward the cisplatin resistant cell line A2780cis.;MicrotubuleAssociated

參考文獻：

1. Flynn BL, et al. Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. J Med Chem. 2011 Sep 8;54(17):6014-27. 2. Kremmidiotis G, et al. BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy. Mol Cancer Ther. 2010 Jun;9(6):1562-73. 3. Inglis DJ, et al. The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer. Cancer Biol Ther. 2014;15(11):1552-60.

溶解性：

Soluble in DMSO

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.686 ml	13.428 ml	26.855 ml
5 mM	0.537 ml	2.686 ml	5.371 ml
10 mM	0.269 ml	1.343 ml	2.686 ml
50 mM	0.054 ml	0.269 ml	0.537 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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