貨號	規格	價格	上海	北京	武漢	南京
S87469-2mg	97.5%	￥120.00 S87469-2mg ￥120.00 現貨	10 10	-	-	-
S87469-5mg	97.5%	￥150.00 S87469-5mg ￥150.00 現貨	10 10	-	-	-
S87469-10mg	97.5%	￥290.00 S87469-10mg ￥290.00 現貨	8 8	-	-	-
S87469-25mg	97.5%	￥500.00 S87469-25mg ￥500.00 現貨	2 2	-	-	-
S87469-50mg	≥97%	￥980.00 S87469-50mg ￥980.00 2-3天	0 貨期：2-3天	-	-	-
S87469-100mg	≥97%	￥1590.00 S87469-100mg ￥1590.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

Mycro 3 is an orally active, potent and selective inhibitor of Myc-associated factor X (MAX) dimerization. Mycro 3 also inhibit DNA binding of c-Myc. Mycro 3 could be used for the research of pancreatic cancer

產品描述：

靶點：

Myc-MAX dimerization;c-Myc;?Autophagy

體外研究：

Mycro 3 is a potent and selective c-Myc inhibitor in whole cell assays, with weak inhibitory activity against Activator protein 1 (AP-1). Mycro 3 has a superior specificity profile to its predecessors. Mycro 3 inhibits the interaction between c-Myc and Max. Mycro 3 has high selectivity and inhibits c-Myc/Max dimerization and conjugation with DNA. Mycro 3 exhibits an excellent specificity with IC50s of 0.25 and 9.0 μM for cells with intact Myc alleles and Myc-null cells, respectively

體內研究：

Mycro 3 (100 mg/kg; oral administration; daily for two months) induces marked shrinkage of pancreatic ductal adenocarcinoma (PDA), increases cancer cell apoptosis, and reduces cell proliferation. Tumor growth is also drastically attenuated in Mycro 3-treated NOD/SCID mice carrying orthotopic or heterotopic xenografts of human pancreatic cancer cells. Animal Model: Moribund Pdx1-cre/KRAS* mice bearing pancreatic ductal adenocarcinoma (PDA) Dosage: 100 mg/kg Administration: Oral administration; daily for two months Result: Increased survival time.Mycro 3 administration was discontinued after two months, the mouse survived for an additional month.

參考文獻：

1. Chen BJ, et al. Small molecules targeting c-Myc oncogene: promising anti-cancer therapeutics. Int J Biol Sci. 2014 Sep 13;10(10):1084-96. 2. Dimitris Stellas, et al. Therapeutic effects of an anti-Myc drug on mouse pancreatic cancer. J Natl Cancer Inst. 2014 Oct 11;106(12):dju320.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.898 ml	9.49 ml	18.98 ml
5 mM	0.38 ml	1.898 ml	3.796 ml
10 mM	0.19 ml	0.949 ml	1.898 ml
50 mM	0.038 ml	0.19 ml	0.38 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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