貨號	規格	價格	上海	北京	武漢	南京
S87422-10mg	99.1%	￥240.00 S87422-10mg ￥240.00 現貨	702 >10	-	-	-
S87422-25mg	99.1%	￥550.00 S87422-25mg ￥550.00 現貨	284 >10	-	-	-
S87422-50mg	99.1%	￥750.00 S87422-50mg ￥750.00 現貨	145 >10	-	-	-
S87422-100mg	99.1%	￥980.00 S87422-100mg ￥980.00 現貨	77 >10	-	-	-

產品介紹

(±)-Equol is the racemate of equol. (±)-equol exhibits EC50s of 200 and 74 nM for human ERα and ERβ, respectively. Equol is a metabolite of the soy isoflavones, daidzin and daidzein.

產品描述：

(±)-Equol is the racemate of equol. (±)-equol exhibits EC50s of 200 and 74 nM for human ERα and ERβ, respectively. Equol is a metabolite of the soy isoflavones, daidzin and daidzein.

靶點：

EstrogenReceptor/ERR;?Estrogen/progestogenReceptor;?DrugMetabolite

體內研究：

Equol is a modest natriuretic and vasorelaxant agent in the rat. Orally administered equol is about 8-fold less potent than orally administered furosemide. In isolated aortic rings precontracted by administration of phenylephrine, administration of equol relaxes the contracted aorta (concentration for half-maximal activity 58.9±16 μM). Equol possesses anticancer activity that suppresses tumor formation via apoptosis induction in rats with mammary gland tumors. In addition, equol shows a hepatic protective effect by acting as an antioxidant and by reducing apoptosis

參考文獻：

1. Axelson M, et al. The identification of the weak oestrogen equol [7-hydroxy-3-(4'-hydroxyphenyl)chroman] in human urine. Biochem J. 1982 Feb 1;201(2):353-7. 2. Setchell KD, et al. S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr. 2005 May;81(5):1072-9. human intestinal bacterial flora. 3. Wang J, et al. Equol promotes rat osteoblast proliferation and differentiation through activating estrogen receptor. Genet Mol Res. 2014 Jul 4;13(3):5055-63. 4. Gimenez I,et al. Renal and vascular actions of equol in the rat. J Hypertens. 1997 Nov;15(11):1303-8. 5. Choi EJ, et al. Anticancer mechanism of equol in 7,12-dimethylbenz(a)anthracene-treated animals. Int J Oncol. 2011 Sep;39(3):747-54. 6. Charoenthongtrakul S, et al. Enhanced gastrointestinal motility with orally active ghrelin receptor agonists. J Pharmacol Exp Ther. 2009;329(3):1178-1186.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	4.127 ml	20.636 ml	41.271 ml
5 mM	0.825 ml	4.127 ml	8.254 ml
10 mM	0.413 ml	2.064 ml	4.127 ml
50 mM	0.083 ml	0.413 ml	0.825 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(2篇)

2. [IF=5.6] Xiaoying Wang et al."The dietary intervention of synbiotic preparation promotes the bioconversion of soy isoflavones to equol and its metabolic mechanism."Journal of Functional Foods.10.1016/j.jff.2023.105784 1. [IF=2.742] Guo Yingyu et al."Isolation and identification of a human intestinal bacterium capable of daidzein conversion."Fems Microbiol Lett. 2021 May;368(8):

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(+/-)-Equol