貨號	規格	價格	上海	北京	武漢	南京
S87394-2mg	99.1%	￥150.00 S87394-2mg ￥150.00 現貨	10 10	-	-	-
S87394-5mg	99.1%	￥230.00 S87394-5mg ￥230.00 現貨	10 10	-	-	-
S87394-10mg	99.1%	￥300.00 S87394-10mg ￥300.00 現貨	8 8	-	-	-
S87394-50mg	99.1%	￥790.00 S87394-50mg ￥790.00 現貨	7 7	-	-	-
S87394-100mg	≥98%	￥1270.00 S87394-100mg ￥1270.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

TC-H 106 (Pimelic Diphenylamide 106)是一種慢速、緊密結合的I類histone deacetylases(HDAC)抑制劑，對HDAC1, HDAC2, HDAC3的Ki值分別為148 nM, 約102 nM, 14 nM

產品描述：

TC-H 106 (Pimelic Diphenylamide 106)是一種慢速、緊密結合的I類histone deacetylases(HDAC)抑制劑，對HDAC1, HDAC2, HDAC3的Ki值分別為148 nM, 約102 nM, 14 nM

靶點：

HDAC3(Cell-free assay):14 nM(Ki);HDAC2(Cell-free assay):~102 nM(Ki)HDAC1(Cell-free assay):148 nM(Ki);HDAC

細胞實驗：

Cell lines: lymphoblastoid cell line Concentrations: 2 μM Incubation Time: 24 h Method: Cells are cultured in RPMI 1640 media with 10% fetal bovine serum and 10 mM HEPES, at 37 °C in 5% CO2. After the 5th split, the cells are treated with inhibitor TC-H 106 (2 μM) for 24 h, in culture medium. 24 h after treatment, the cells are washed twice with Hanks' balanced salts buffer to remove the inhibitor. A portion of the cell population is then harvested immediately after washing, and referred to as a time 0 point (24 h treatment point), and the rest of the cells are then re-cultured in cell culture media without added inhibitor. The re-cultured cells and controls are then harvested every hour for a total of 7 h.

參考文獻：

1. Chou CJ, et al. J Biol Chem. 2008 19;283(51):35402-9.

溶解性：

Soluble in DMSO、Ethanol

保存條件：

2-8℃，避光

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.946 ml	14.731 ml	29.461 ml
5 mM	0.589 ml	2.946 ml	5.892 ml
10 mM	0.295 ml	1.473 ml	2.946 ml
50 mM	0.059 ml	0.295 ml	0.589 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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