貨號	規(guī)格	價格	上海	北京	武漢	南京	購買數(shù)量
S87353-5mg	≥99%	￥2500.00 S87353-5mg ￥2500.00 2-3天	0 貨期：2-3天	-	-	-
S87353-10mg	≥99%	￥4600.00 S87353-10mg ￥4600.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.

產(chǎn)品描述：

CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.

靶點(diǎn)：

Nrf2/ARE;Nrf2

體外研究：

CDDO-EA potently activates Nrf2/ARE in a cell culture model of ALS and in the G93A SOD1 mouse model of ALS. CDDO-EA is a potent inducer of apoptosis in A549 lung cancer cells, as shown both by PARP cleavage and Annexin staining. CDDO-EA is more potent than CDDO itself as inducers of heme oxygenase-1 (HO-1). In RAW264.7 macrophage-like cells, CDDO-EA is 7-fold more potent than CDDO as suppressors of the ability of IFN-γ to induce iNOS

體內(nèi)研究：

The survival analysis shows that G93A mice treated with CDDO-EA, compared to G93A littermate controls, lives significantly longer. CDDO-EA treatment increases the life-span by 20.6 days from 124.05±3.7 days to 144.72±8.1 days (16.6%) (p<0.001). In CDDO-EA-treated G93A mice, the age of death is 141.4±5.2 days and the duration from the age of onset to the age of death is 57.6±7.6 days, which means that the age of death from onset is prolonged by 17.5 days (43%)

參考文獻(xiàn)：

1. Neymotin A, et al. Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. Free Radic Biol Med. 2011 Jul 1;51(1):88-96. 2. Liby K, et al. The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice. Cancer Res. 2007 Mar 15;67(6):2414-9.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.928 ml	9.639 ml	19.278 ml
5 mM	0.386 ml	1.928 ml	3.856 ml
10 mM	0.193 ml	0.964 ml	1.928 ml
50 mM	0.039 ml	0.193 ml	0.386 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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