品牌	貨號(hào)	產(chǎn)品規(guī)格	價(jià)格(RMB)	庫(kù)存（上海）	北京	武漢	南京
源葉(MedMol)	S87130-5mg	98%	￥425.00元	4	-	-	-
源葉(MedMol)	S87130-10mg	98%	￥590.00元	4	-	-	-
源葉(MedMol)	S87130-25mg	98%	￥1180.00元	5	-	-	-
源葉(MedMol)	S87130-100mg	98%	￥3500.00元	3	-	-	-

產(chǎn)品介紹

MSX-122 (Q-122)是一種新型的CXCR4部分拮抗劑，IC50約為10 nM

產(chǎn)品描述：

MSX-122 (Q-122)是一種新型的CXCR4部分拮抗劑，IC50約為10 nM

靶點(diǎn)：

CXCR4:~10 nM;CXCR

體外研究：

MSX-122 is also incapable of blocking the binding of 125I-labeled CXCL12 to CXCR4. MSX-122 appears to be insufficiently large to block all binding sites between CXCR4 and CXCL12. MSX-122 blocks certain CXCR4 functions via binding to the CXCL12-binding site and interfering with CXCR4/CXCL12-mediated signaling. MSX-122 can intervene in the Gαi-signaling pathway (cAMP modulation), but not the Gq-pathway (calcium flux)

體內(nèi)研究：

MSX-122 blocks bleomycin-induced lung fibrosis involving chemotaxis and homing of CXCR4-positive mesenchymal progenitor cells into the lungs. MSX-122 exhibits anti-inflammatory activity in a carrageenan-induced paw edema model. MSX-122 blocks lung metastasis of breast cancer and SCCHN, and liver metastasis of uveal melanoma in vivo

細(xì)胞實(shí)驗(yàn)：

Cell lines: MDA-MB-231 cells Concentrations: 1, 10, 100, and 1000 nM Incubation Time: 15 mins Method: For binding affinity assay, MDA-MB-231 cells cultured in an 8-well slide chamber are preincubated with MSX-122 at 1, 10, 100, and 1000 nM. Then the cells are fixed with 4% formaldehyde and incubated with 50 nM biotinylated TN14003, and followed by Rhodamine staining.

動(dòng)物實(shí)驗(yàn)：

Animal Models: Male C57BL/6 mice (age 5–6 weeks) Dosages: 10 mg/kg Administration: i.p. injection

參考文獻(xiàn)：

1. Liang Z, et al. Development of a unique small molecule modulator of CXCR4. PLoS One. 2012, 7(4):e34038.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.421 ml	17.103 ml	34.207 ml
5 mM	0.684 ml	3.421 ml	6.841 ml
10 mM	0.342 ml	1.71 ml	3.421 ml
50 mM	0.068 ml	0.342 ml	0.684 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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MSX-122 98%

MSX-122