貨號	規格	價格	上海	北京	武漢	南京
S87090-5mg	99.1%	￥2250.00 S87090-5mg ￥2250.00 現貨	6 6	-	-	-
S87090-10mg	99.1%	￥3200.00 S87090-10mg ￥3200.00 現貨	7 7	-	-	-
S87090-25mg	99.1%	￥5400.00 S87090-25mg ￥5400.00 現貨	6 6	-	-	-

產品介紹

DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 10.3 μM and 1.09 μM, respectively.

產品描述：

DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 10.3 μM and 1.09 μM, respectively.

靶點：

DNMT1:1.09 μM (Kd);DNMT1:10.3 μM (IC50);PRMT1:37.1 μM (IC50);DNAMethyltransferase;HistoneMethyltransferase

體外研究：

DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 10.3 μM and 1.09 μM, respectively. DC-05 shows less potent activities against DNMT3A, DNMT3B, G9a, SUV39H1, MLL1, SET7/9, and PRMT1 (IC50: >200, >200, >150, >150, >150, >150, 37.1 μM). DC-05 (1.25, 2.5, 5, and 10 μM) potently inhibits the proliferation of HCT116 (human colon cancer) and Capan-1 (human pancreatic adenocarcinoma cells) after treatment for 24, 48, and 72 h

參考文獻：

1. Chen S, et al. Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening. J Med Chem. 2014 Nov 13;57(21):9028-41.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.608 ml	13.038 ml	26.077 ml
5 mM	0.522 ml	2.608 ml	5.215 ml
10 mM	0.261 ml	1.304 ml	2.608 ml
50 mM	0.052 ml	0.261 ml	0.522 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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