貨號	規格	價格	上海	北京	武漢	南京
S87041-5mg	99.7%	￥420.00 S87041-5mg ￥420.00 現貨	8 8	-	-	-
S87041-10mg	99.7%	￥670.00 S87041-10mg ￥670.00 現貨	9 9	-	-	-
S87041-25mg	99.7%	￥1500.00 S87041-25mg ￥1500.00 現貨	9 9	-	-	-
S87041-50mg	99.7%	￥2700.00 S87041-50mg ￥2700.00 現貨	12 >10	-	-	-

產品介紹

HC-067047 is a potent and selective TRPV4 antagonist and reversibly inhibits currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 48 nM, 133 nM, and 17 nM, respectively

產品描述：

HC-067047 is a potent and selective TRPV4 antagonist and reversibly inhibits currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 48 nM, 133 nM, and 17 nM, respectively

靶點：

IC50: 48 nM (human TRPV4), 133 nM (rat TRPV4), 17 nM (mouse TRPV4);TRP/TRPVChannel

體內研究：

HC-067047 (0-50 mg/kg; intraperitoneal injection; for 30 minutes; cyclophosphamide-treated WT and Trpv4?/? mice, and naive WT mice) treatment increases functional bladder capacity and reduces micturition frequency in WT mice with cystitis. HC-067047 do not affect bladder function in Trpv4?/? mice. Animal Model: Cyclophosphamide-treated WT and Trpv4?/? mice, and naive WT mice[1] Dosage: 0 mg/kg, 1 mg/kg, 10 mg/kg, 50 mg/kg Administration: Intraperitoneal injection; for 30 minutes Result: Increased functional bladder capacity and reduces micturition frequency in WT mice with cystitis and did not affect bladder function in Trpv4?/? mice.

參考文獻：

1. Everaerts W et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19084-9. 2. Xing Y, et al. Decreased Expression of TRPV4 Channels in HEI-OC1 Cells Induced by High Glucose Is Associated with Hearing Impairment. Yonsei Med J. 2018 Nov;59(9):1131-1137.

溶解性：

Soluble in DMSO

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.119 ml	10.593 ml	21.186 ml
5 mM	0.424 ml	2.119 ml	4.237 ml
10 mM	0.212 ml	1.059 ml	2.119 ml
50 mM	0.042 ml	0.212 ml	0.424 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(1篇)

1. [IF=7.129] Miao Guo et al."Co-exposure to particulate matter and humidity increases blood pressure in hypertensive mice via the TRPV4-cPLA2-COX2 pathway."ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY.2023 Apr;255:114800

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HC-067047

2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide