貨號	規(guī)格	價格	上海	北京	武漢	南京
S87005-5mg	≥98%	￥900.00 S87005-5mg ￥900.00 2-3天	0 貨期：2-3天	-	-	-
S87005-10mg	≥98%	￥1500.00 S87005-10mg ￥1500.00 2-3天	0 貨期：2-3天	-	-	-
S87005-50mg	≥98%	￥3800.00 S87005-50mg ￥3800.00 2-3天	0 貨期：2-3天	-	-	-
S87005-100mg	≥98%	￥4800.00 S87005-100mg ￥4800.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

(E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol (HY-14616), is a potent Nrf2 activator. (E)-[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells

產(chǎn)品描述：

(E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol (HY-14616), is a potent Nrf2 activator. (E)-[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells

靶點：

Nrf2

體外研究：

(E)-[6]-Dehydroparadol (M15) (5-80 μM; 24 h) inhibits the growth of HCT-116 and H-1299 cells, with IC50s of 43.02 and 41.59 μM, respectively. (E)-[6]-Dehydroparadol (10-40 μM; 24 h) induces apoptosis in HCT-116 and H-1299 cells

體內(nèi)研究：

(E)-[6]-Dehydroparadol (compound 19) (5 μM; 24 h) enhances Tg[glutathione S-transferase pi 1 (gstp1):green fluorescent protein (GFP)] fluorescence signal in the Tg(gstp1:GFP) transgenic zebrafish embryos

參考文獻：

1. Chen H, et, al. Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human. Mol Nutr Food Res. 2013 May;57(5):865-76. 2. Zhu Y, et, al. Synthesis, evaluation, and metabolism of novel [6]-shogaol derivatives as potent Nrf2 activators. Free Radic Biol Med. 2016 Jun;95:243-54.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.618 ml	18.092 ml	36.183 ml
5 mM	0.724 ml	3.618 ml	7.237 ml
10 mM	0.362 ml	1.809 ml	3.618 ml
50 mM	0.072 ml	0.362 ml	0.724 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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