貨號	規(guī)格	價格	上海	北京	武漢	南京
S86956-5mg	99.9%	￥265.00 S86956-5mg ￥265.00 現(xiàn)貨	3210 >10	-	-	-
S86956-10mg	99.9%	￥523.00 S86956-10mg ￥523.00 現(xiàn)貨	1610 >10	-	-	-
S86956-25mg	99.9%	￥650.00 S86956-25mg ￥650.00 現(xiàn)貨	653 >10	-	-	-
S86956-50mg	99.9%	￥940.00 S86956-50mg ￥940.00 現(xiàn)貨	330 >10	-	-	-
S86956-100mg	99.9%	￥1330.00 S86956-100mg ￥1330.00 現(xiàn)貨	170 >10	-	-	-
S86956-200mg	99.9%	￥1990.00 S86956-200mg ￥1990.00 現(xiàn)貨	90 >10	-	-	-

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產品介紹

Dabigatran etexilate mesylate is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI, Ki: 4.5 nM).

產品描述：

Dabigatran etexilate mesylate is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI, Ki: 4.5 nM).

靶點：

Thrombin

體內研究：

Dabigatran prolonged the aPTT dose-dependently after intravenous administration in rats (0.3, 1 and 3 mg/kg) and rhesus monkeys (0.15, 0.3 and 0.6 mg/kg). Dose- and time-dependent anticoagulant effects were observed with dabigatran etexilate administered orally to conscious rats (10, 20 and 50 mg/kg) or rhesus monkeys (1, 2.5 or 5 mg/kg), with maximum effects observed between 30 and 120 min after administration, respectively. Patients treated with dabigatran etexilate experienced fewer ischaemic strokes (3.74 dabigatran etexilate vs 3.97 warfarin) and fewer combined intracranial hemorrhages and hemorrhagic strokes (0.43 dabigatran etexilate vs 0.99 warfarin) per 100 patient-years

參考文獻：

1.Kansal AR, Sorensen SV, Gani R, Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in UK patients withatrial fibrillation. Heart. 2012 Apr;98(7):573-8. 2.Wienen W, Stassen JM, Priepke H, In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally activeprodrug, dabigatran etexilate. Thromb Haemost. 2007 Jul;98(1):155-62.

溶解性：

Soluble in DMSO

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.382 ml	6.908 ml	13.815 ml
5 mM	0.276 ml	1.382 ml	2.763 ml
10 mM	0.138 ml	0.691 ml	1.382 ml
50 mM	0.028 ml	0.138 ml	0.276 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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Dabigatran Etexilate Mesylate