貨號	規格	價格	上海	北京	武漢	南京
S86858-5mg	99.1%	￥240.00 S86858-5mg ￥240.00 現貨	6 6	-	-	-
S86858-10mg	99.1%	￥385.00 S86858-10mg ￥385.00 現貨	7 7	-	-	-
S86858-50mg	99.1%	￥1070.00 S86858-50mg ￥1070.00 現貨	1 1	-	-	-

產品介紹

AF-353 (Ro-4) is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3

產品描述：

AF-353 (Ro-4) is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3

靶點：

pIC50: 8.0 (human P2X3), 8.0 (rat P2X3), 7.3 (human P2X2/3);P2XReceptor

體內研究：

AF-353 (Ro-4) does not compromise oxygen levels or cardiac function. AF-353 (Ro-4) (10 mg/kg, 20 mg/kg; i.v.; for 4-6 hours) inhibits the purinergic response in both normal and spinal cord-injured (SCI) rats. AF-353 (Ro-4) (10 mg/kg, 20 mg/kg; i.v.; for 4-6 hours) also reduces the inter-contractile interval in normal but not in SCI rats; however, the frequency of non-voiding (NVC) in SCI rats is significantly reduced

參考文獻：

1. Gever JR, et al. AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010 Jul;160(6):1387-1398. 2. Munoz A, et al. Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3receptors. BJU Int. 2012 Oct;110(8 Pt B):E409-414.

溶解性：

Soluble in DMSO

保存條件：

2-8℃，避光

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.499 ml	12.493 ml	24.987 ml
5 mM	0.5 ml	2.499 ml	4.997 ml
10 mM	0.25 ml	1.249 ml	2.499 ml
50 mM	0.05 ml	0.25 ml	0.5 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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AF-353 ( Ro-4)

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-