貨號	規格	價格	上海	北京	武漢	南京
S86733-5mg	≥98%	￥870.00 S86733-5mg ￥870.00 2-3天	0 貨期：2-3天	-	-	-
S86733-10mg	≥98%	￥1720.00 S86733-10mg ￥1720.00 2-3天	0 貨期：2-3天	-	-	-
S86733-50mg	≥98%	￥6500.00 S86733-50mg ￥6500.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

Cevipabulin (TTI-237) is an oral, microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line

產品描述：

Cevipabulin (TTI-237) is an oral, microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line

靶點：

IC50: 18-40 nM (microtubule in human tumor cells);MicrotubuleAssociated

體內研究：

Cevipabulin (TTI-2370)( 5, 10, 15, and 20 mg/kg, every 4 days for 4 cycles, in mice) is active by i.v. and p.o. administration against human tumor xenografts, showing dose-dependent effects, with good antitumor activity at 20 and 15 mg/kg. Animal Model: Athymic nu/nu female mice implanted s.c. in the flank with 1×107 LoVo human colon adenocarcinoma cells Dosage: 5, 10, 15, and 20 mg/kg Administration: I.V. injection every 4 days for 4 cycles. Result: The compound showed dose-dependent effects, with good antitumor activity at 20 and 15 mg/kg.

參考文獻：

1. Beyer CF, et al. TTI-237: a novel microtubule-active compound with in vivo antitumor activity. Cancer Res. 2008 Apr 1;68(7):2292-300. 2. Beyer CF, et al. The microtubule-active antitumor compound TTI-237 has both paclitaxel-like and vincristine-like properties. Cancer Chemother Pharmacol. 2009 Sep;64(4):681-9.

溶解性：

Soluble in DMSO

保存條件：

2-8℃，避光

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.151 ml	10.757 ml	21.514 ml
5 mM	0.43 ml	2.151 ml	4.303 ml
10 mM	0.215 ml	1.076 ml	2.151 ml
50 mM	0.043 ml	0.215 ml	0.43 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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Cevipabulin (TTI-237)

5-Chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-((1S)-2,2,2-trifluoro-1-methylethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine