貨號	規(guī)格	價格	上海	北京	武漢	南京	購買數(shù)量
S86715-5mg	98%	￥2720.00 S86715-5mg ￥2720.00 現(xiàn)貨	11 >10	-	-	-
S86715-10mg	98%	￥4080.00 S86715-10mg ￥4080.00 現(xiàn)貨	12 >10	-	-	-

產(chǎn)品介紹

(S)-Selisistat ((S)-EX-527) is a potent and selective SIRT1 inhibitor, with an IC50 of 98 nM.

產(chǎn)品描述：

(S)-Selisistat ((S)-EX-527) is a potent and selective SIRT1 inhibitor, with an IC50 of 98 nM.

靶點：

SIRT1：98 nM (IC50);Sirtuin

體內研究：

(S)-Selisistat abolishes Resveratrol (RSV)-induced attenuation of microvascular inflammation in ob/ob septic mice. Finally, ob/ob mice in Sepsis+RSV group has significantly increased 7-day survival vs. Sepsis+Vehicle group

參考文獻：

1. Solomon JM, et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006 Jan;26(1):28-38. 2. Jia Y, et al. SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells. PLoS One. 2015 Mar 20;10(3):e0120849. 3. Wang X, et al. Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice. Obesity (Silver Spring). 2015 Jun;23(6):1209-17. 4. Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54.

溶解性：

Soluble in DMSO

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	4.021 ml	20.104 ml	40.207 ml
5 mM	0.804 ml	4.021 ml	8.041 ml
10 mM	0.402 ml	2.01 ml	4.021 ml
50 mM	0.08 ml	0.402 ml	0.804 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(3篇)

3. [IF=4.2] Decheng Meng et al."Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic SIRT1/PGC-1α pathway."EUROPEAN JOURNAL OF PHARMACOLOGY.2024 Aug;977:176737 2. [IF=2] Xu Yanmei et al."Astragalus polysaccharide attenuates diabetic nephropathy by reducing apoptosis and enhancing autophagy through activation of Sirt1/FoxO1 pathway."INTERNATIONAL UROLOGY AND NEPHROLOGY".2024 Apr;:1-12 1. [IF=4.36] Pin Gong et al."Hypoglycemic effect of astragaloside IV via modulating gut microbiota and regulating AMPK/SIRT1 and PI3K/AKT pathway."J Ethnopharmacol. 2021 Dec;281:114558

質檢證書(COA)

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批號：JS298415 貨號：S20001-25g
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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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體積

分子摩爾量

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EX-527(S-enantiomer)

EX527