貨號	規(guī)格	價格	上海	北京	武漢	南京
S86649-5mg	99.2%	￥260.00 S86649-5mg ￥260.00 現(xiàn)貨	5 5	-	-	-
S86649-10mg	99.2%	￥450.00 S86649-10mg ￥450.00 現(xiàn)貨	7 7	-	-	-
S86649-25mg	99.2%	￥960.00 S86649-25mg ￥960.00 現(xiàn)貨	6 6	-	-	-
S86649-50mg	≥99%	￥1600.00 S86649-50mg ￥1600.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α

產(chǎn)品描述：

Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α

靶點：

IC50: less than 1 μM (p38α);p38MAPK;Autophagy

體外研究：

Acumapimod is an inhibitor of p38α with an IC50 value of less than 1 μM.

體內(nèi)研究：

Acumapimod is an oral low-molecular-weight p38 inhibitor currently in development for the treatment of several inflammatory conditions, including chronic obstructive pulmonary disease (COPD). Intermittent short-term dosing of Acumapimod (75 mg on days 1 and 6) shows a marked improvement in lung function in COPD patients

參考文獻：

1. Norman P, et al. Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2015 Mar;24(3):383-92. 2. De Buck S, et al. Population PK-PD Model for Tolerance Evaluation to the p38 MAP Kinase Inhibitor BCT197. CPT Pharmacometrics Syst Pharmacol. 2015 Dec;4(12):691-700.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.595 ml	12.973 ml	25.946 ml
5 mM	0.519 ml	2.595 ml	5.189 ml
10 mM	0.259 ml	1.297 ml	2.595 ml
50 mM	0.052 ml	0.259 ml	0.519 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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