貨號	規(guī)格	價格	上海	北京	武漢	南京	購買數(shù)量
S86632-5mg	≥98%	￥940.00 S86632-5mg ￥940.00 2-3天	0 貨期：2-3天	-	-	-
S86632-10mg	≥98%	￥1610.00 S86632-10mg ￥1610.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM.

產(chǎn)品描述：

Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM.

靶點：

IC50: 35 nM (Aldose Reductase);Reductase

體內(nèi)研究：

Tolrestat (1.8 mg/kg per day) causes a reversal to normal RBC sorbitol levels diabetic rats. In 21-day diabetic rats, the estimated ID in the sciatic nerve and lenses is 4.8 and about 20 for tolrestat, and 1.7 and 2.2 for (±)sorbinil, respectively. Either tolrestat or sorbinil inhibits tissue AR activity but does not significantly affect plasma lipoprotein levels, or affect the body weight of the mice or their general health. Accumulation of cholesterol-rich foam cells is significantly increased in aortic roots of tolrestat-fed mice

參考文獻：

1. Sestanj K, et al. N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor. J Med Chem. 1984 Mar;27(3):255-6. 2. Simard-Duquesne N, et al. The effects of a new aldose reductase inhibitor (tolrestat) in galactosemic and diabetic rats. Metabolism. 1985 Oct;34(10):885-92. 3. Srivastava S, et al. Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice. Circ Res. 2009 Oct 9;105(8):793-802.

溶解性：

Soluble in DMSO

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.798 ml	13.992 ml	27.984 ml
5 mM	0.56 ml	2.798 ml	5.597 ml
10 mM	0.28 ml	1.399 ml	2.798 ml
50 mM	0.056 ml	0.28 ml	0.56 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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TOLRESTAT