貨號	規格	價格	上海	北京	武漢	南京
S86605-5mg	99.4%	￥300.00 S86605-5mg ￥300.00 現貨	105 >10	-	-	-
S86605-10mg	99.4%	￥480.00 S86605-10mg ￥480.00 現貨	54 >10	-	-	-
S86605-25mg	99.4%	￥740.00 S86605-25mg ￥740.00 現貨	25 >10	-	-	-
S86605-50mg	99.4%	￥1250.00 S86605-50mg ￥1250.00 現貨	15 >10	-	-	-

產品介紹

JNJ-17203212 is a selective, potent and competitive TRPV1 antagonist. JNJ-17203212 is developed for researching pain management, such as migraine

產品描述：

JNJ-17203212 is a selective, potent and competitive TRPV1 antagonist. JNJ-17203212 is developed for researching pain management, such as migraine

靶點：

TRPV1;TRP/TRPVChannel

體內研究：

JNJ-17203212 (0.3 mg/kg; i.v.) dose-dependently reduces inflammatory soup (IS)-induced the immediate early gene c-fos expression. JNJ-17203212 completely blocks capsaicin-induced CGRP (the neurotransmitter calcitonin gene-related peptide) release in a dose-dependent manner. Animal Model: Male Sprague-Dawley rats (260-300 g) Dosage: 0.3 mg/kg Administration: Intravenous injection Result: Had a dose-dependent effect on the elevated c-fos expression that occurred after intracisternal injection of IS.

參考文獻：

1. Xingjuan Chen, et al. Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel.J Biol Chem. 2014 Apr 4; 289(14): 9600-9610. 2. Jannis E Meents, et al. Two TRPV1 receptor antagonists are effective in two different experimental models of migraine. J Headache Pain. 2015; 16: 57.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.387 ml	11.933 ml	23.866 ml
5 mM	0.477 ml	2.387 ml	4.773 ml
10 mM	0.239 ml	1.193 ml	2.387 ml
50 mM	0.048 ml	0.239 ml	0.477 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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JNJ-17203212

4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide