| 產(chǎn)品描述： | iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT), with IC50 of 40.3 nM against Wnt responsive STF16 luciferase. |
| 靶點(diǎn)： |
IC50: 40.3 nM (Wnt responsive STF16 luciferase);Wnt/beta-catenin |
| 體內(nèi)研究： |
iCRT14 (50 mg/kg, i.p.) markedly decreases CycD1, proliferation of the tumors in HCT116 xenografts |
| 參考文獻(xiàn)： |
1. Gonsalves FC, et al. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci USA. 2011 Apr 12;108(15):5954-63. 2. Bilir B, et al. Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells. J Transl Med. 2013 Nov 4;11:280. |
| 溶解性： |
Soluble in DMSO |
| 保存條件： |
2-8℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.664 ml |
13.318 ml |
26.635 ml |
| 5 mM |
0.533 ml |
2.664 ml |
5.327 ml |
| 10 mM |
0.266 ml |
1.332 ml |
2.664 ml |
| 50 mM |
0.053 ml |
0.266 ml |
0.533 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
上海工商
危險(xiǎn)品化學(xué)品經(jīng)營許可證（不帶存儲(chǔ)）
營業(yè)執(zhí)照(三證合一)
北京