貨號	規格	價格	上海	北京	武漢	南京
S85977-25mg	99.1%	￥60.00 S85977-25mg ￥60.00 現貨	3 3	-	-	-
S85977-100mg	99.1%	￥140.00 S85977-100mg ￥140.00 現貨	7 7	-	-	-
S85977-500mg	99.1%	￥350.00 S85977-500mg ￥350.00 現貨	8 8	-	-	-

產品介紹

DHBP dibromide is an inhibitor for calcium release and a muscle relaxant.

產品描述：

DHBP dibromide is an inhibitor for calcium release and a muscle relaxant.

靶點：

Calcium Channel;CalciumChannel

體外研究：

DHBP inhibits the calcium release induced by 2 mM caffeine and 2 μg/mL polylysine with an IC50 value of 5 μg/mL and 4 μg/mL, respectively. DHBP inhibits [3H]-ryanodine binding in a dose-dependent manner with an IC50 of 2.5 μg/mL and 90-100% inhibition at 20-30 μg/mL. Calcium uptake by SR is inhibited in the presence of caffeine and this inhibition is antagonized by concomitant addition of DHBP. Muscle twitches elicited by direct electrical muscle stimulation and contractions induced by either 10 mM caffeine or 1 fLM ryanodine are blocked by pretreatment with DHBP. DHBP blocks the calcium release from SR by direct interaction with the calcium release channel, also known as the ryanodine receptor.

參考文獻：

1. Kang JJ, et al. Effects of bipyridylium compounds on calcium release from triadic vesicles isolated from rabbit skeletal muscle. Br J Pharmacol. 1994 Aug;112(4):1216-22.

溶解性：

Soluble in DMSO、H2O

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.944 ml	9.72 ml	19.441 ml
5 mM	0.389 ml	1.944 ml	3.888 ml
10 mM	0.194 ml	0.972 ml	1.944 ml
50 mM	0.039 ml	0.194 ml	0.389 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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體積

分子摩爾量

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DHBP dibromide ( Diheptylviologen dibromide)

1,1'-Diheptyl-[4,4'-bipyridine]-1,1'-diium bromide