貨號	規格	價格	上海	北京	武漢	南京
S85921-5mg	99.9%	￥204.00 S85921-5mg ￥204.00 現貨	5 5	-	-	-
S85921-10mg	99.9%	￥340.00 S85921-10mg ￥340.00 現貨	5 5	-	-	-
S85921-25mg	99.9%	￥697.00 S85921-25mg ￥697.00 現貨	3 3	-	-	-
S85921-50mg	99.9%	￥1020.00 S85921-50mg ￥1020.00 現貨	2 2	-	-	-
S85921-100mg	≥98%	￥1955.00 S85921-100mg ￥1955.00 2-3天	0 貨期：2-3天	-	-	-
S85921-200mg	≥98%	￥3570.00 S85921-200mg ￥3570.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

OAC2 is an Oct4 activator which activates expression through the Oct4 gene promoter; enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts; an analog of OAC1.

產品描述：

靶點：

OCT

細胞實驗：

The Oct4-luc or Nanog-luc cells are treated with compound OAC1 or its structural analogs OAC2, OAC3 at 1 μM concentration or at indicated concentrations. Other compounds used include 2 μM BIO, 2 μM BIX, 2 μM 5'-azacytidine, 25 μg/mL Vitamin C, 10 nM Am580, 5 μM tranylcypromine, and 0.5 mM valporic acid. Luciferase reporter assays are performed 24 h after compound treatment or at indicated time points. For Topflash reporter assays, 0.2 μg β-catenin–responsive Topflash reporter gene plasmid is introduced into CV1 cells using trasfection. Compounds are added 6 h after transfection. Luciferase activity is measured 48 h after compound treatment using the Glo Luciferase Assay System

參考文獻：

1Li W, et al. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20853-8. 2.Okuyama T, et al. Structural and mechanistic insights into nuclear transport and delivery of the critical pluripotency factor Oct4 to DNA. J Biomol Struct Dyn. 2017 Feb 6:1-50

溶解性：

Soluble in DMSO

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	4.232 ml	21.162 ml	42.324 ml
5 mM	0.846 ml	4.232 ml	8.465 ml
10 mM	0.423 ml	2.116 ml	4.232 ml
50 mM	0.085 ml	0.423 ml	0.846 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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N-(1H-Indol-5-yl)benzamide