貨號	規格	價格	上海	北京	武漢	南京
S85645-5mg	≥98%	￥750.00 S85645-5mg ￥750.00 2-3天	0 貨期：2-3天	-	-	-
S85645-10mg	≥98%	￥1100.00 S85645-10mg ￥1100.00 2-3天	0 貨期：2-3天	-	-	-
S85645-50mg	≥98%	￥3600.00 S85645-50mg ￥3600.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

Prinaberel (ERB-041) is a potent and selective estrogen receptor (ER) β agonist with IC50s of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. Prinaberel displays >200-fold selectivity for ERβ over ERα. Prinaberel is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. Prinaberel induces ovarian cancer apoptosis

產品描述：

靶點：

hERβ：5.4 nM (IC50)；rat Erβ：3.1 nM (IC50)；mouse Erβ：3.7 nM (IC50)；hERα：1200 nM (IC50)；mouse Erα：750 nM (IC50)；rat Erα：620 nM (IC50);Estrogen/progestogenReceptor

體內研究：

Prinaberel (2mg/mouse; topically; 30 min prior to UVB irradiation for 30 weeks) suppresses development of squamous cell carcinoma in SKH-1 hairless mice. Prinaberel reduces proliferation and angiogenesis and induces apoptosis in UVB-induced skin tumors. Prinaberel suppresses pro-inflammatory signaling pathway in UVB-induced skin tumors. Prinaberel diminished tumor invasiveness via PI3K-AKT pathway and WNT signaling Animal Model: Six- to eight-weeks-old SKH-1 hairless female mice Dosage: 2 mg/mouse in 200μl ethanol Administration: Topically; 30 min prior to UVB (180mJ/cm2) irradiation for 30 weeks Result: Diminished UVB-induced skin tumor development in SKH-1 hairless mice.

參考文獻：

1. Malamas MS, et al. Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004;47(21):5021-5040. 2. Chaudhary SC, et al. Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. Cancer Prev Res (Phila). 2014;7(2):186-198. 3. Chan KKL, et al. Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer. Cancer Cell Int. 2018;18:65. Published 2018

溶解性：

Soluble in DMSO

保存條件：

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.687 ml	18.434 ml	36.868 ml
5 mM	0.737 ml	3.687 ml	7.374 ml
10 mM	0.369 ml	1.843 ml	3.687 ml
50 mM	0.074 ml	0.369 ml	0.737 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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ERB 041