貨號	規(guī)格	價格	上海	北京	武漢	南京
S85641-2mg	99.4%	￥357.00 S85641-2mg ￥357.00 現(xiàn)貨	5 5	-	-	-
S85641-5mg	99.4%	￥620.00 S85641-5mg ￥620.00 現(xiàn)貨	6 6	-	-	-
S85641-10mg	99.4%	￥1020.00 S85641-10mg ￥1020.00 現(xiàn)貨	6 6	-	-	-
S85641-25mg	99.4%	￥2210.00 S85641-25mg ￥2210.00 現(xiàn)貨	6 6	-	-	-
S85641-50mg	≥99%	￥3500.00 S85641-50mg ￥3500.00 2-3天	0 貨期：2-3天	-	-	-
S85641-100mg	≥99%	￥5100.00 S85641-100mg ￥5100.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

SW044248 is a non-canonical topoisomerase I inhibitor, and selectively toxic for certain non-small cell lung cancer (NSCLC) cell lines

產(chǎn)品描述：

SW044248 is a non-canonical topoisomerase I inhibitor, and selectively toxic for certain non-small cell lung cancer (NSCLC) cell lines

靶點：

Topoisomerase I;Topoisomerase

體外研究：

SW044248 is a non-canonical Top1 inhibitor, and is selectively toxic for certain NSCLC cell lines. SW044248 shows no effect on Top2. SW044248 (2, 5, 10 μM) rapidly inhibits transcription, translation and DNA synthesis in sensitive cells (HCC4017 and H292 cells) but not insensitive cells (HBEC30KT cells and HCC44 cells). SW044248 (10 μM) rapidly activates the integrated stress response through kinases GCN2 and PKR. The inhibition of Top1 in HCC4017 cells is helpful to the toxicity of SW044248. SW044248 (5, 10 μM) shows no effect on HBEC30KT and HCC44 cell lines due to the up-regulation of p21CDKN1A. SW044248 is selectively toxic in 18/74 NSCLC lines

參考文獻：

1. Zubovych IO, et al. A Novel Inhibitor of Topoisomerase I Is Selectively Toxic for a Subset of Non-Small Cell Lung Cancer Cell Lines. Mol Cancer Ther. 2016 Jan;15(1):23-36. 2. Kim HS, et al. Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer. Cell. 2013 Oct 24;155(3):552-66.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.372 ml	11.862 ml	23.724 ml
5 mM	0.474 ml	2.372 ml	4.745 ml
10 mM	0.237 ml	1.186 ml	2.372 ml
50 mM	0.047 ml	0.237 ml	0.474 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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