貨號	規格	價格	上海	北京	武漢	南京
S85604-5mg	99.1%	￥690.00 S85604-5mg ￥690.00 現貨	126 >10	-	-	-
S85604-10mg	99.1%	￥1200.00 S85604-10mg ￥1200.00 現貨	65 >10	-	-	-
S85604-25mg	99.1%	￥1900.00 S85604-25mg ￥1900.00 現貨	33 >10	-	-	-
S85604-100mg	≥99%	￥5500.00 S85604-100mg ￥5500.00 現貨	5 5	-	-	-

產品介紹

Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.

產品描述：

Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.

靶點：

AChE

體外研究：

Galanthaminone reduces the action of AChE and therefore tends to increase the concentration of acetylcholine in the brain. is also an allosteric ligand at nicotinic acetylcholine receptors. It has shown activity in modulating the nicotinic cholinergic receptors on cholinergic neurons to increase acetylcholine release.

體內研究：

Absorption of Galanthaminone is rapid and complete and shows linear pharmacokinetics. It is well absorbed with absolute oral bioavailability between 80 and 100%. It has a half-life of seven hours. Peak effect of inhibiting acetylcholinesterase was achieved about one hour after a single oral dose of 8 mg in some healthy volunteers.

參考文獻：

1. Greenblatt HM, et al. Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution. FEBS Lett. 1999 Dec 17;463(3):321-6. 2. Heinrich M, et al. Galanthamine from snowdrop--the development of a modern drug against Alzheimer's disease from local Caucasian knowledge. J Ethnopharmacol. 2004 Jun;92(2-3):147-62.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.505 ml	17.523 ml	35.046 ml
5 mM	0.701 ml	3.505 ml	7.009 ml
10 mM	0.35 ml	1.752 ml	3.505 ml
50 mM	0.07 ml	0.35 ml	0.701 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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Galanthaminone