貨號	規格	價格	上海	北京	武漢	南京
S85485-1mg	99.4%	￥150.00 S85485-1mg ￥150.00 現貨	10 10	-	-	-
S85485-5mg	99.4%	￥255.00 S85485-5mg ￥255.00 現貨	7 7	-	-	-
S85485-10mg	99.4%	￥500.00 S85485-10mg ￥500.00 現貨	5 5	-	-	-
S85485-25mg	99.4%	￥860.00 S85485-25mg ￥860.00 現貨	4 4	-	-	-
S85485-50mg	≥98%	￥1470.00 S85485-50mg ￥1470.00 2-3天	0 貨期：2-3天	-	-	-
S85485-100mg	≥98%	￥2390.00 S85485-100mg ￥2390.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

Lersivirine (UK-453061) is potent and selective non-nucleoside reverse transcription inhibitor (NNRTI; IC50=119 nM) with excellent efficacy against NNRTI-resistant viruses. Lersivirine exhibits potent antiretroviral activity against wild-type HIV virus and clinically relevant NNRTI-resistant strains

產品描述：

靶點：

IC50: 119 nM (NNRT);HIVProtease;ReverseTranscriptase

體內研究：

Lersivirine (oral gavage; 0, 150, 350, and 500 mg/kg; once daily; gestation days 6 to 17, followed by cesarean section on gestation day 18. ) allows induction of hepatic metabolizing enzymes at the first 2 days at 250 mg/kg, after which the dose is increased to 500 mg/kg/day in Mated Crl:CD1(ICR) mice. Lersivirine leads to skeletal variations which related to delayed development and decreased fetal ossifications

參考文獻：

1. Mowbray CE, et al. Pyrazole NNRTIs 4: selection of UK-453,061 (lersivirine) as a development candidate. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5857-60. 2. Gregg D Cappon, et al. Developmental toxicity study of lersivirine in mice. Birth Defects Res B Dev Reprod Toxicol. 2012 Jun;95(3):225-30.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.222 ml	16.111 ml	32.222 ml
5 mM	0.644 ml	3.222 ml	6.444 ml
10 mM	0.322 ml	1.611 ml	3.222 ml
50 mM	0.064 ml	0.322 ml	0.644 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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