貨號	規格	價格	上海	北京	武漢	南京
S85457-1mg	≥99%	￥240.00 S85457-1mg ￥240.00 現貨	9 9	-	-	-
S85457-5mg	99.0%	￥600.00 S85457-5mg ￥600.00 現貨	12 >10	-	-	-
S85457-10mg	99.0%	￥1040.00 S85457-10mg ￥1040.00 現貨	11 >10	-	-	-
S85457-25mg	99.0%	￥2000.00 S85457-25mg ￥2000.00 現貨	2 2	-	-	-
S85457-50mg	99.0%	￥3840.00 S85457-50mg ￥3840.00 現貨	5 5	-	-	-

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產品介紹

Ko 143 is a potent and selective ATP-binding cassette subfamily G member 2 (ABCG2/BCRP) inhibitor. Ko 143 displays >200-fold selectivity over P-gp and MRP-1 transporters

產品描述：

Ko 143 is a potent and selective ATP-binding cassette subfamily G member 2 (ABCG2/BCRP) inhibitor. Ko 143 displays >200-fold selectivity over P-gp and MRP-1 transporters

靶點：

EC90: 26 nM (BCRP);BCRP;ABC

體內研究：

Ko143 (10 mg/kg, p.o.) increases the oral availability of SKF 104864A in mice. Ko143 significantly affects the pharmacokinetics of ZD 4522 in rats

參考文獻：

1. Weidner LD, et al. The Inhibitor Ko143 Is Not Specific for ABCG2. J Pharmacol Exp Ther. 2015 Sep;354(3):384-93. 2. JD Allen et al. Potent and Specific Inhibition of the Breast Cancer Resistance Protein Multidrug Transporter in Vitro and in Mouse Intestine by a Novel Analogue of Fumitremorgin C. Mol. Cancer Ther. 2002, 1, 417-425. 3. Wen JH, et al. Effect of Ursolic Acid on Breast Cancer Resistance Protein-mediated Transport of ZD 4522 In Vivo and Vitro. Chin Med Sci J. 2015 Dec;30(4):218-25. 4. Hou J, et al. Quantitative determination and pharmacokinetic study of the novel anti-Parkinson's disease candidate drug FLZ in rat brain by high performance liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2012 Jul;66:232-9. 5. Liu K, et al. Metabolism of KO143, an ABCG2 inhibitor. Drug Metab Pharmacokinet. 2017 Aug;32(4):193-200.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.13 ml	10.648 ml	21.296 ml
5 mM	0.426 ml	2.13 ml	4.259 ml
10 mM	0.213 ml	1.065 ml	2.13 ml
50 mM	0.043 ml	0.213 ml	0.426 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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