貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S85393-2mg	99.6%	￥272.00 S85393-2mg ￥272.00 現(xiàn)貨	8 8	-	-	-
S85393-5mg	99.6%	￥503.20 S85393-5mg ￥503.20 現(xiàn)貨	8 8	-	-	-
S85393-10mg	99.6%	￥748.00 S85393-10mg ￥748.00 現(xiàn)貨	8 8	-	-	-
S85393-25mg	99.6%	￥1496.00 S85393-25mg ￥1496.00 現(xiàn)貨	6 6	-	-	-
S85393-50mg	99.6%	￥2650.00 S85393-50mg ￥2650.00 現(xiàn)貨	4 4	-	-	-
S85393-100mg	≥98%	￥3800.00 S85393-100mg ￥3800.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3 nM

產(chǎn)品描述：

WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3 nM

靶點(diǎn)：

IC50: 2.3 nM (ERRβ), 155 nM (ERRα);EstrogenReceptor/ERR;Estrogen/progestogenReceptor

體外研究：

Administration of WAY-200070 (30 mg/kg s.c.) causes nuclear translocation of ERRβ receptors in WT mice. Administration of WAY-200070 (30 mg/kg s.c.) produces a delayed 50% increase in dopamine in the striatum of wild type mice. WAY-200070 (30 mg/kg s.c.) reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator. WAY-200070, shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test

參考文獻(xiàn)：

1. Hughes ZA, et al. WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent. Neuropharmacology. 2008 Jun;54(7):1136-42. 2. Clipperton Allen AE, et al. Agonistic behavior in males and females: effects of an estrogen receptor beta agonist in gonadectomized and gonadally intact mice. Psychoneuroendocrinology. 2010 Aug;35(7):1008-22. 3. Clipperton AE, et al. Differential effects of estrogen receptor alpha and beta specific agonists on social learning of food preferences in female mice. Neuropsychopharmacology. 2008 Sep;33(10):2362-75. 4. Weiser MJ, et al. Estrogen receptor-beta agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress. Endocrinology. 2009 Apr;150(4):1817-25.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.267 ml	16.334 ml	32.668 ml
5 mM	0.653 ml	3.267 ml	6.534 ml
10 mM	0.327 ml	1.633 ml	3.267 ml
50 mM	0.065 ml	0.327 ml	0.653 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶(hù)參考交流研究之用。

參考文獻(xiàn)

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