貨號	規格	價格	上海	北京	武漢	南京
S85180-50mg	98.7%	￥110.00 S85180-50mg ￥110.00 現貨	5 5	-	-	-
S85180-250mg	≥98%	￥330.00 S85180-250mg ￥330.00 2-3天	0 貨期：2-3天	-	-	-
S85180-1g	≥98%	￥750.00 S85180-1g ￥750.00 2-3天	0 貨期：2-3天	-	-	-
S85180-5g	≥98%	￥2590.00 S85180-5g ￥2590.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

Tenofovir alafenamide fumarate (GS-7340 fumarate) is an investigational oral proagent of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.

產品描述：

Tenofovir alafenamide fumarate (GS-7340 fumarate) is an investigational oral proagent of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.

靶點：

HIV-1;HIV-2;HIVProtease

體外研究：

Tenofovir alafenamide fumarate (GS-7340 fumarate) antiviral activities are similar across all cell types, ranging from 5 to 7 nM, while the CC50 varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively. The antiviral activity of TAF is evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 group M subtypes A to G, as well as group N and O isolates. Overall, for the 29 primary HIV-1 isolates tested in PBMCs, TAF EC50s range from 0.1 to 12 nM, with a mean EC50 of 3.5 nM compared to a mean EC50 of 11.8 nM for AZT, which is used as an internal control. For the HIV-2 isolates, the mean EC50s are 1.8 nM for TAF and 6.4 nM for AZT

體內研究：

Tenofovir alafenamide fumarate (GS-7340 fumarate) is an amidate prodrug of Tenofovir with good oral bioavailability and increases plasma stability compared to Tenofovir disoproxil fumarate (TDF)

參考文獻：

1. Babusis D, et al. Mechanism for effective lymphoid cell and tissue loading following oral administration of nucleotide prodrug GS-7340. Mol Pharm. 2013 Feb 4;10(2):459-66. 2. Ruane PJ, et al. Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of tenofovir alafenamide as 10-day monotherapy in HIV-1-positive adults. J Acquir Immune Defic Syndr. 2013 Aug 1;63(4):449-55.

溶解性：

Soluble in DMSO、H2O

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.688 ml	8.438 ml	16.877 ml
5 mM	0.338 ml	1.688 ml	3.375 ml
10 mM	0.169 ml	0.844 ml	1.688 ml
50 mM	0.034 ml	0.169 ml	0.338 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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GS-7340 (fumarate)