貨號	規格	價格	上海	北京	武漢	南京
S85159-5mg	99.0%	￥260.00 S85159-5mg ￥260.00 現貨	6 6	-	-	-
S85159-10mg	99.0%	￥430.00 S85159-10mg ￥430.00 現貨	7 7	-	-	-
S85159-25mg	99.0%	￥860.00 S85159-25mg ￥860.00 現貨	6 6	-	-	-
S85159-100mg	≥99%	￥3000.00 S85159-100mg ￥3000.00 2-3天	0 貨期：2-3天	-	-	-

產品介紹

Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.

產品描述：

Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.

靶點：

AMPA receptor;iGluR

體內研究：

Incubation of Mibampator (LY451395) with Actinoplanes missouriensis NRRL B3342 generated several metabolites that were previously detected in the in vivo metabolism studies of the preclinical species. LY404187 and Mibampator (LY451395) reverses the central effects of an acutely intoxicating dose of ethanol in the rat. Mibampator (LY451395) significantly and dose-dependently reversed ethanol-induced deficits in both motor coordination and disruptions in an operant task where animals were trained to press a lever for food reward

參考文獻：

1. Zmijewski M, et al. Application of biocatalysis to drug metabolism: preparation of mammalian metabolites of a biaryl-bis-sulfonamide AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor potentiator using Actinoplanes missouriensis. Drug Metab Dispos. 2006 Jun;34(6):925-31. 2. Jones N, et al. AMPA receptor potentiation can prevent ethanol-induced intoxication. Neuropsychopharmacology. 2008 Jun;33(7):1713-23.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.28 ml	11.4 ml	22.8 ml
5 mM	0.456 ml	2.28 ml	4.56 ml
10 mM	0.228 ml	1.14 ml	2.28 ml
50 mM	0.046 ml	0.228 ml	0.456 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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Mibampator

(R)-N-(2-(4'-(2-(methylsulfonamido)ethyl)-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide