貨號	規格	價格	上海	北京	武漢	南京
S85127-5mg	98.9%	￥288.00 S85127-5mg ￥288.00 現貨	10 10	-	-	-
S85127-10mg	98.9%	￥512.00 S85127-10mg ￥512.00 現貨	7 7	-	-	-
S85127-50mg	98.9%	￥1920.00 S85127-50mg ￥1920.00 現貨	4 4	-	-	-
S85127-100mg	98.9%	￥3520.00 S85127-100mg ￥3520.00 現貨	2 2	-	-	-

產品介紹

Carbetocin, an oxytocin (OT) analogue, is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin has high affinity to chimeric N-terminus (E1) of the oxytocin receptor (Ki=1.17 μM). Carbetocin has the potential for postpartum hemorrhage research. Carbetocin can crosse the blood-brain barrier and produces antidepressant-like activity via activation of oxytocin receptors in the CNS

產品描述：

靶點：

Oxytocin Receptor;OxytocinReceptor

體內研究：

Carbetocin (2-20 mg/kg; i.p.) has a significant effect of treatment on the percent time spent climbing, swimming and immobile. Carbetocin (1, 10,100 μg/rat, i.c.v.) reveals a dose-dependent increase in the percent time spent swimming and a corresponding reduction in immobility following acute administration of 100 μg/rat

參考文獻：

1. Stella Chaviaras, et al. Assessing the antidepressant-like effects of carbetocin, an oxytocin agonist, using a modification of the forced swimming test. Psychopharmacology (Berl). 2010 May;210(1):35-43. 2. Gerald Gimpl, et al. Binding domains of the oxytocin receptor for the selective oxytocin receptor antagonist barusiban in comparison to the agonists oxytocin and carbetocin. Eur J Pharmacol. 2005 Mar 7;510(1-2):9-16. 3. David Feifel, et al. The effects of oxytocin and its analog, carbetocin, on genetic deficits in sensorimotor gating. Eur Neuropsychopharmacol. 2012 May;22(5):374-8.

溶解性：

Soluble in DMSO、H2O

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.012 ml	5.06 ml	10.12 ml
5 mM	0.202 ml	1.012 ml	2.024 ml
10 mM	0.101 ml	0.506 ml	1.012 ml
50 mM	0.02 ml	0.101 ml	0.202 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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