貨號	規格	價格	上海	北京	武漢	南京
S85100-1mg	≥98%	￥520.00 S85100-1mg ￥520.00 2-3天	0 貨期：2-3天	-	-	-
S85100-2mg	≥98%	￥800.00 S85100-2mg ￥800.00 2-3天	0 貨期：2-3天	-	-	-
S85100-5mg	99.4%	￥1440.00 S85100-5mg ￥1440.00 現貨	4 4	-	-	-
S85100-10mg	99.4%	￥1920.00 S85100-10mg ￥1920.00 現貨	5 5	-	-	-
S85100-25mg	99.4%	￥2400.00 S85100-25mg ￥2400.00 現貨	7 7	-	-	-
S85100-100mg	99.4%	￥5120.00 S85100-100mg ￥5120.00 現貨	1 1	-	-	-

產品介紹

C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages

產品描述：

C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages

靶點：

TLR

體外研究：

C29 blunts hTLR2/1 and hTLR2/6 signaling in HEK-TLR2 Stable transfectants and THP-1 Cells. C29 blocks P3C- and P2C-induced IL-8 mRNA dose-dependently in HEK-TLR2 stable transfectants. C29 also inhibits P3C- and P2C-induced IL-1β gene expression significantly at both 1 h and 4 h following stimulation, as well as both P3C- and P2C-induced NF-κB–luciferase activity in transiently transfected HEK293T cells expressing hTLR2 and an NF-κB–sensitive luciferase reporter construct. C29 preferentially inhibits TLR2/1 signaling in primary murine macrophages. C29 blocks TLR2 bacterial agonist-induced proinflammatory gene expression in HEK-TLR2 Cells and murine macrophages. C29 inhibits ligand-induced interaction of TLR2 with MyD88 and blocks MAPK and NF-κB activation

體內研究：

C29L inhibits TLR2/1-induced inflammation in mice. Mice treated twice with C29L before administration of P3C significantly blocks IL-12 p40 and TNF-α liver cytokine mRNA and serum protein. C29L has a significant inhibitory effect at the later time point for IL-12 p40

參考文獻：

1. Mistry P, et al. Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5455-60. 2. Du J, Li J, Zhu J, et al. Structural characterization and immunomodulatory activity of a novel polysaccharide from Ficus carica[J]. Food & function. 2018 Jul 17;9(7):3930-3943. 3. Li Y, Niu M, Zhao A, et al. CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson’s disease[J]. Journal of Neuroinflammation. 2019, 16(1): 1-14. 4. Jiang S, Yin H, Qi X, et al. Immunomodulatory effects of fucosylated chondroitin sulfate from Stichopus chloronotus on RAW 264.7 cells[J]. Carbohydrate Polymer. 2020, 251: 117088. 5. Wen Y, Peng D, Li C, et al. A new polysaccharide isolated from Morchella importuna fruiting bodies and its immunoregulatory mechanism[J]. International Journal of Biological Macromolecules. 2019, 137: 8-19.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.505 ml	17.526 ml	35.051 ml
5 mM	0.701 ml	3.505 ml	7.01 ml
10 mM	0.351 ml	1.753 ml	3.505 ml
50 mM	0.07 ml	0.351 ml	0.701 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(2篇)

2. [IF=7.7] Jinyan Gu et al."Identification of an arabinogalactan with special structure from Moringa Oleifera Lam. leaf and exploration of its immunomodulatory activity."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2024 Aug;:134616 1. [IF=5.7] Jinyan Gu et al."Highly Branched Rhamnogalacturonan-I Type Pectin from Wolfberry: Purification, Characterization, and Structure-Prebiotic/Immunomodulatory Activity Relationship."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2024;XXXX(XXX):XXX-XXX

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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C29

TLR2-IN-C29