貨號	規格	價格	上海	北京	武漢	南京
S85030-1mg	99.2%	￥285.60 S85030-1mg ￥285.60 現貨	8 8	-	-	-
S85030-5mg	99.2%	￥680.00 S85030-5mg ￥680.00 現貨	5 5	-	-	-
S85030-10mg	99.2%	￥1156.00 S85030-10mg ￥1156.00 現貨	6 6	-	-	-
S85030-25mg	99.2%	￥2448.00 S85030-25mg ￥2448.00 現貨	6 6	-	-	-
S85030-50mg	99.2%	￥4624.00 S85030-50mg ￥4624.00 現貨	5 5	-	-	-

產品介紹

AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties

產品描述：

靶點：

hJNK1:150 nM (IC50);hJNK2:220 nM (IC50);hJNK3:70 nM (IC50);JNK

體外研究：

AS601245, an anti-Inflammatory JNK inhibitor, and Clofibrate have a synergistic effect in inducing cell responses and in affecting the gene expression profile in CaCo-2 colon cancer cells

體內研究：

AS601245 (40, 60, and 80 mg/kg; i.p.) provides significant protection against the delayed loss of hippocampal CA1 neurons in a gerbil model of transient global ischemia. AS601245 (0.3-10 mg/kg; p.o.) is a potent inhibitor of LPS-induced TNF-α release in mice. Animal Model: C3H/HEN mice Dosage: 0.3, 1, 3, or 10 mg/kg Administration: P.o. Result: Decreased the TNF-α release in a dose-dependent manner.

參考文獻：

1. Carboni S, et al. AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties. J Pharmacol Exp Ther. 2004;310(1):25-32.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.685 ml	13.425 ml	26.85 ml
5 mM	0.537 ml	2.685 ml	5.37 ml
10 mM	0.268 ml	1.342 ml	2.685 ml
50 mM	0.054 ml	0.268 ml	0.537 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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